things that increase/decrease MAC Flashcards

1
Q

MAC definition

A

the partial pressure of an inhalation anesthetic at 1 atmosphere that prevents skeletal muscle movement in response to surgical skin incision in 50% of the population

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2
Q

The lower the MAC, the more ___ the agent, and the ___ the blood:gas partition coefficient

A

potent, higher

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3
Q

hypoxia

A

decrease

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4
Q

infants

A

increase

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5
Q

MAC usually greatest in

A

newborn

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6
Q

anemia

A

decrease

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7
Q

hyperthermia

A

increase

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8
Q

lithium

A

decrease

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9
Q

chronic alcohol and drug use

A

increase

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10
Q

sedatives

A

decrease

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11
Q

red heads

A

increase

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12
Q

pregnancy

A

decrease

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13
Q

hypothermia

A

decrease

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14
Q

hypotension

A

decrease

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15
Q

hyperthermia if >42C

A

decrease

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16
Q

decreased PAO2

A

decrease

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17
Q

hematocrit <10%

A

decrease

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18
Q

decreased MAP

A

decrease

19
Q

PAO2 >95mmHG

A

decreased caused by

20
Q

elderly

A

decrease

21
Q

thyroid

A

no change

22
Q

CCB’s

A

decrease

23
Q

acute ETOH ingestion

A

decrease

24
Q

hypercalcemia

A

decrease

25
Q

decreased CBF

A

decrease

26
Q

decreased CMRO2

A

decrease

27
Q

hypernatremia

A

increase

28
Q

hyponatremia

A

decrease

29
Q

local anesthetics

A

decrease

30
Q

cocaine as a local anesthetic

A

increase

31
Q

sympathomimetic drugs (cocaine,ephedrine, amphetamine)

A

increase

32
Q

chronic amphetamine

A

decrease

33
Q

levodopa

A

increase (apex)

34
Q

lidocaine

A

decrease (apex)

35
Q

alpha 2 agonists

A

decrease(apex)

36
Q

cardiopulmonary bypass

A

decrease(apex)

37
Q

hypo-osmolarity

A

decrease (apex)

38
Q

metabolic acidosis

A

decrease (apex)

39
Q

hyperkalemia

A

does not affect! (apex)

40
Q

hypokalemia

A

does not affect! (apex)

41
Q

hypermagnesemia

A

does not affect! (apex)

42
Q

hypomagnesemia

A

does not affect! (apex)

43
Q

hypertension

A

does not affect! (apex)