Thickening of GBM Flashcards
What causes the thickening of the glomerular basement membrane (GBM)?
The thickening of the GBM can occur due to the deposition of immune complexes (as in membranous glomerulonephritis), increased synthesis of its protein components (as in diabetic glomerulosclerosis), or interposition of mesangial cells.
How can the thickening of the GBM be visualized under light microscopy?
The thickening of the GBM is best observed using a PAS stain (Periodic Acid-Schiff stain).
What is the role of immune complexes in causing GBM thickening?
Immune complexes can deposit in the glomeruli, leading to inflammation and thickening of the GBM. This is a characteristic feature of membranous glomerulonephritis.
What is the significance of increased synthesis of protein components in GBM thickening?
In conditions like diabetic glomerulosclerosis, increased synthesis of protein components of the GBM can lead to its thickening, contributing to kidney damage in diabetes
How do mesangial cells contribute to GBM thickening?
Mesangial cells can interpose themselves within the glomerular basement membrane, leading to its thickening and structural changes. This can be seen in certain pathological conditions.
What staining technique is most effective for observing thickening of the GBM under light microscopy?
The PAS stain (Periodic Acid-Schiff stain) is the most effective staining technique for visualizing the thickening of the glomerular basement membrane under light microscopy.
