Hypercellularity

Question 1

Question: What is hypercellularity, and in which conditions is it seen?

Answer 1

Hypercellularity refers to an increased number of cells in the glomeruli. It is observed in some inflammatory glomerulonephritis (GN) conditions.

Question 2

What are the possible reasons for hypercellularity in inflammatory GNs?

Answer 2

Hypercellularity in inflammatory GNs can be due to the proliferation of mesangial, endothelial, or epithelial cells, as well as leucocyte infiltration.

Question 3

How does crescent formation occur, and what does it involve?

Answer 3

Crescent formation occurs when proliferating parietal cells and infiltrating leucocytes occlude more than one-third of a glomerulus. This happens in response to fibrin leakage into the urinary space

Question 4

What is the significance of crescent formation?

Answer 4

Crescent formation is associated with severe glomerular injury and is a feature of advanced inflammatory glomerulonephritis.

Question 5

What is the role of leucocytes in hypercellularity?

Answer 5

Leucocytes contribute to hypercellularity in some inflammatory glomerulonephritis cases by infiltrating the glomeruli.

Question 6

What is the result of fibrin leakage into the urinary space in terms of glomerular structure?

Answer 6

Fibrin leakage into the urinary space can lead to the formation of crescents, where proliferating parietal cells and infiltrating leucocytes occlude more than one-third of the glomerulus