Thiazide Diuretics Flashcards
1
Q
What is the thiazide diuretic used in treatment?
A
- Bendroflumethiazide
2
Q
What are the indications of bendroflumethiazide?
A
- Hypertension
- Diabetes insipidus
3
Q
What are the containdications of bendroflumethiazide?
A
- Severe electrolyte disturbance
- Acute gout
- Addisons disease
4
Q
What are examples of the electrolyte disturbances caused by bendroflumethiazide?
A
- Hyponatraemia
- Hypokalaemia
- Hypercalcaemia
5
Q
Cautions of bendroflumethiazide?
A
- Gout
- Diabetes mellitus
- Renal impairment
- Hepatic impairment
- Pregnancy and breast feeding
6
Q
What process do thiazide diuretics increase loss of fluid?
A
- Normally the Na/KATPase pump at the distal tubule in the kidney maintains a high Na conc and allows water to return
- Thiazides block the transporter and diuresis occurs
7
Q
How should bendroflumethiazide be administered?
A
- Orally
- Low dose
8
Q
What are the adverse reactions of bendroflumethiazide?
A
- Hypokalaemia
- Hyponatraemia
- Hypomagneaemia
- Hypercalcaemia
- Hyperuricacidaemia
- Hyperlipidaemia
- Impotence
- Blood disorders (thrombocytopenia)
9
Q
What drug interactions are there for bendroflumethiazide?
A
- NSAIDs reduce their effects
- Lithium excretion reduced that can lead to toxicity
10
Q
What can hypokalaemia from bendroflumethiazide cause?
A
- Digoxin toxicity if being used with
- Anti-arrhythmic toxicity
