Therapy of infectious diseases Flashcards

1
Q

How do you treat infectious diseases?

A
  • start treatment as soon as possible

– before occurrence of severe morphologic or functional changes

  • medical doctors have to make some functional test to understand the most probable diagnosis before starting antibiotic treatment
  • symptoms like fever, nausea, vomiting, diarrhea, dehydration, seizures, bleeding are typical for infectious diseases to be suspicious
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2
Q

What is involved in the treatment of infectious diseases?

A
  • bed rest, appropriative diet, etiological, pathogenetic, simptomatic, physiothepary, rehabilitation
  • the treatment has to be estimated or changed every day according to the changes in the patient’s laboratory data or patient’s general condition
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3
Q

Why do we advise bed rest in treatment of infectious diseases?

A

aims: peace of harmed organs, less waste of energy, soon recovery, lack of complications

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4
Q

What are some requirements for bed rest?

A
  • fresh air in room
  • good ventilation
  • comfortable temperature
  • care for teeth, skin
  • changes in position in the bed
  • cares for passing and defecation – it has to be regularly; if is need urinary catheter could be used or some drugs for overcoming of constipation
  • prophylaxis of hypostatic pneumonia – deep breathing, massages of the thorax and spine, changes the position in the bed
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5
Q

What does diet consist of in relation to a patient with an infectious disease?

A
  • specific qualitative and quantitative composition, energy value and culinary cultivation which main aim is treatment
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6
Q

What are the basic principles of diet?

A
  • diet has to be consistent with the present infectious disease and its organ complications
  • diet has to be consistent with the present clinical form of infectious diseases and has to be changed when the patient’s conditions is changed
  • diet has to answer to patient’s energy needs
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7
Q
A
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8
Q

Describe how the lymphoid progenitor gives rise to the B and T lymphocytes and natural killer cells

A

Lymphoid progenitor -> depending on which interleukin is involved -> differentiate into T or B cells

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9
Q

Describe the cytokines necessary for the colony-forming unit to give rise to monocytes and neutrophils

A
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10
Q

Describe the cytokines necessary for the colony-forming unit to give rise to basophils, eosinophils, platelets, and erythrocytes

A
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11
Q

Which of the following is responsible for the maturation and release of eosinophils from the bone marrow?

A

Interleukin-5

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12
Q

Which of the given interleukin families stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells?

A

Interleukin-3

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13
Q

Define acute myeloid leukemia (AML) and its clinical presentation

A
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14
Q

Identify the different types of cytogenetic abnormalities and the type of AML associated with each

A

t(15;17)
t(8;21)

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15
Q

Describe the clinical presentation in myelodysplastic syndrome (MDS)

A
  • the precursor of AML
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16
Q

Describe the appearance of myeloid blasts in AML

A
  • contain Auer Rods
17
Q

Describe the appearance of myeloid blasts in acute promyelocytic leukemia (APL or M3 AML)

A
18
Q

Identify the antibody against which the azurophilic granules in APL myeloid blasts stain positive

A
19
Q

Describe the FAB classification of AML

A
20
Q

Identify the treatment of APL associated with disseminated intravascular coagulation (DIC)

A
21
Q

Which of the following cytogenetic abnormalities are associated with acute promyelocytic leukemia?

A

t(15;17)

22
Q

Which of the following translocations is associated with acute myeloblastic leukemia?

A

t(8;21)

23
Q

Which of values represents the percentage of blast cells in pre-leukemic conditions?

A

less than 20%

24
Q

Which of the following is seen in acute promyelocytic Leukemia-M3?

A

Auer rods

25
Q

What does the FAB classification categorize M6 as?

A

Acute erythroid leukemia

26
Q

Which of the following subtypes corresponds to acute promyelocytic leukemia?

A

FAB subtype M3

27
Q

Which of the following classes of acute myeloid leukemia can be treated with all-trans retinoic acid?

A

Acute promyelocytic leukemia