Therapeutics of HF Flashcards

1
Q

What is gold standard for diagnosing HF?

A

Echocardigography

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2
Q

Why don’t we have evidence based therapies for HFpEF?

A

Inclusion criteria for trials was EF

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3
Q

When can you rule out HF?

A

Normal ECG and Normal BNP

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4
Q

Prognosis of HF vs cancers

A

HF prognosis is worse than every other cancer except lung cancer

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5
Q

Medical therapies for HF

A

ACEi
Aldosterone antagonists
B-blockers

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6
Q

Next step after medical therapy in HF

A
Exercise training (some evidence)
±CRT-P/D
Cardiac resynchronisation therapy
Extra pacemaker lead, improves function of heart by taking a dysynchronous ventricle and making it contract to give a more useful cardiac output
P (pacing)
D (defibrillator) Usually both
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7
Q

First line treatment in HF

A

ACEi

standard procedure but could give b-blocker first also

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8
Q

CI of ACEi

A

Angioedema (v rare)
Bilateral renal artery stenosis
Pregnancy/risk of pregnancy

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9
Q

Cautions with ACEi

A

Hyperkalaemi, renal dysfunction, severe hypotension

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10
Q

How often are beta blockers given in HF

A

Pretty much everyone

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11
Q

CI of beta blocker

A

Asthmatics

2/3rd degree AV block/conduction block

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12
Q

What stage of therapy are aldosterone antagonists in HF

A

3rd class

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13
Q

Why would you give aldosterone antagonists in HF?

A

To more severe HF

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14
Q

Is COPD a CI for beta blocker?

A

NO

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15
Q

Why do patients not take HF medication well

A

mage of HF does not carry connotations that it is actually worse than most cancers

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16
Q

Difference between observation data and RCT

A

Confounding in observational. RCT only sure way to tell if a drug works

17
Q

Decrease in risk of death in HF patient by taking carvedilol

A

35% - huge

18
Q

Why are less pts on beta blockers in US?

A

Payment at point of care

19
Q

How are side effects leaflets in medication packets decided on? Problem with this?

A

Questionnaires to patients. Not scientifically based. Regression to mean of symptoms

20
Q

What role to clinicians play in compliance of taking medication?

A

More clinicians mention the adverse effects than the benefit. Pts will definitely live substantially longer with the treatment than without it

21
Q

B blocker increase in survival in HF?

A

5 months

22
Q

ACEi increase in survival in HF?

A

6months

23
Q

Cumulative addition of HF drug therapy

A

Triple therapy triples life span

24
Q

Why are RCTs not representative of the population being treated

A

Young, reliable, articulate patients

25
Q

Problem with elderly in RCTs

A

Therapeutic effect will fall due to other coexisting disease

26
Q

Normal practice for ACE-I/ARB/aldosterone antagonists

A

To start: Accept Cr<220 and K>5.5
Keep SBP>90mmHg
Once started accept Cr<266, K5.5

27
Q

Next option after triple therapy

A

LCZ696 (entresto) A combination of
• Valsartan (ARB)
• Sacubitril (neprilysin inhibitor)