Intro to atherosclerosis Flashcards
1
Q
Main cell types
A
- Vascular Endothelial cells
- Platelets
- Macrophages
- Vascular SM cells
- T lymphocytes
2
Q
Role of Vascular Endothelial cells
A
Barrier
Leukocyte recruitment
3
Q
Role of Macrophages
A
Foam cell formation
Cytokine and GF release
Major source of free radicals
Metalloproteinases
4
Q
Role of platelets
A
Thrombus formation
Cytokine and GF release (including PDGF)
5
Q
Role of vascular SM cells
A
Migration and proliferation
Collagen synthesis
Remodelling and fibrous cap formation
6
Q
Role of T lymphocytes
A
Macrophage activation
7
Q
What are macrophages and relevance to atherosclerosis
A
WBC
Main inflammatory cells of atherosclerosis
8
Q
What are macrophages derived from
A
Blood monocytes
9
Q
How are macrophage subtypes regulated
A
Combinations of transcription factors binding to regulatory sequences on DNA
10
Q
Main classes of macrophages
A
1.
