Therapeutics of COPD

Question 1

What is COPD

Answer 1

• emphysema and bronchitis

- cough, sputum and increasing dysponea

Question 2

Assessment of COPD

Answer 2

look at how much bronchospasm, infection, right heart failure and emphysema

Question 3

Pharmacological Management of COPD

Answer 3

1. Inhaled bronchodilator
   - —-B2 agonists (SABA + LABA)
   - —-Antimuscarinics (SAMA (ipatropium), LAMA (tiotropium)
2. Inhaled corticosteroids
3. Oral bronchodilators - theophylline

Question 4

Tiotropium

Answer 4

• long acting muscarinic antagonist (bronchodilator)
• preferrable to SAMA’s
• other LAMA’s - glycopyronium and aclidium

Question 5

Extra managment of COPD

Answer 5

• abx when needed
• vaccination (flu and pneumococcal)
• mucolytics (carbocysteine)
• smoking cessation
• treat heart failure
• O2 therapy for respiratory failure

Question 6

Managing exacerbations of COPD

Answer 6

• controlled O2
• corticosteroids
• Abx
• bronchodilators
• physiotherapy

Question 7

Smoking cessation methods

Answer 7

Nicotine replacement
Prescription medicine (not with NRT)
- bupropion tablets - antidepressant
- varencicline tablets - selective nicotine receptor partial agonist
- both contraindicated if <18/pregnant/breastfeeding