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3: Therapeutics Lecture Day > Therapeutics Of ⬆️BP > Flashcards

Therapeutics Of ⬆️BP Flashcards

0
Q

Why endothelium factors affect BP?

A

Endothelin
NO
…

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1
Q

BP=

A

CO x TPR

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2
Q

What happens to systolic pressure with ⬆️ age?

A

⬆️

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3
Q

What happens to diastolic pressure with ⬆️ age?

A

Rises, plateaus at 50, can even ⬇️ slightly

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4
Q

Causes of secondary ⬆️BP?

A 
Renal
Endocrine
Genetic 
CoA (coarctation of aorta) eg Turner's
Mediations
Poisons
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5
Q

What drugs can cause ⬆️BP?

A

NSAIDs

Oral contraceptive pill

Cyclosporins

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6
Q

What poisoning can give ⬆️BP?

A

Lead poisoning

Alternative medicines

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7
Q

Main endocrine syndromes that cause ⬆️BP?

A

PCC

Conn’s (⬆️ aldosterone)- tumour or hypertrophy of fireball glands

Cushing’s (⬆️ glucocorticoids)

Acromegaly (⬆️ GH)

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8
Q

What genetic conditions cause ⬆️BP?

A

CAH (congenital adrenal hyperplasia)

GRA (glucocorticoid remediable aldosteronism)

AME (apparent mineralocorticoid excess)

Liddle’s syndrome - ENac channel

Gordon’s syndrome

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9
Q

What happens to the aorta in Turner’s syndrome?

A

CoA

Coarctation of aorta

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10
Q

Target organ damage in ⬆️BP

A

Micro vascular disease
Atherosclerosis
LVF
Renal disease

AAA - rarer
-more common in men

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11
Q

What microvascular conditions can ⬆️BP cause?

A

Hypertensive renal disease

Retinopathy

Cerebral microaneurysms

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12
Q

What drug are recommended for under 55s with ⬆️BP?

A

ACE inhibitors

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13
Q

What’s the issue of giving ACE inhibitors to women of child baring age?

A

ACE inhibitors are highly teratogenic in the first trimester

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14
Q

Side effects if ACE inhibitors

A 
Cough (10%)
⬆️kalaemia
ARF
Skin rash
Angioedema (⬆️ bradykinin)
Hepatotoxicity
Teratogenic
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15
Q

What are he 3 types I Ca channel blockers?

A

Dihydropyridines (amlodipine) - ankle swelling

Benzothiazepines

16
Q

ADR of thiazides

A

⬇️natreamia

…

17
Q

What can increase in patients taking a-blockers?

A

CCF

18
Q

Name a central a-blocker

A

Clonidine

Sedation

19
Q

Name a common aldosterone antagonist

A

Spirinolactone

Gynaecomastia

20
Q

Define a hypertensive emergency?

A

> 180/110 mmHg

Acute damage to target organs

Requires intravenous therapy

21
Q

What is hypertensive urgency?

A

180/110 mmHg

No acute target organ damage

Requires GRADUAL reduction

22
Q
A 
Acute LVF
Ureania with volume overload
CVA/SHA
SOL
Encephalitis
Drugs & toxins
Hypercalcaemia
23
Q

If a women BP is over … /… mm Hg medicate them

A

150/110 mmHg

3: Therapeutics Lecture Day (5 decks)

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