Therapeutics

Question 1

effects of steroids

Answer 1

1. stabilize cells and lysosomal membranes
2. reduce vascular sm. musc sensitivity to histamine
3. inhibit release of histamine
4. decr. adherence and migration of neutrophils
5. decr. production of IL-1 (pro inflam)

Question 2

lotrisone

Answer 2

topical agent that combines ultra potent topical steroid with anti fungal agent (clotrimazole)

Question 3

med e.g. for each topical steroid class

Answer 3

I: ultrapotent, clobetasol proprionate 0.05%
II: high potent, fluocinonide 0.05%
IV: mid potent, triamcinolone acetone 0.1%
VII: low potent, hydrocortisone cream 1%

Question 4

propylene glycol

Answer 4

humectant and solvent

may cause contact dermatitis

Question 5

formaldehyde

Answer 5

preservative with high incidence of allergic contact dermatitis

Question 6

calcineurin inhibitors

Answer 6

anti inflam

inhibits t cell activation and cytokine production

tacrolimus and pimecrolimus