Dermis and SubQ Flashcards
type I coll
primary coll of derm
Ehlers Danlos syndrome (EDS)
Type I
- hypermobile joints
- excess stretching, maintain elastic
- fragile skin
- atrophic “fish mouth” scars
Type IV
-bl vessels involvement –> bruising, GI, art rupture
pseudoxanthoma elasticum (PXE)
auto rec
clumping of elastic fibers –> affects skin, eyes, cardio
yellow papillose of lat neck and axillae
ocular involvement
findings clinically apparent in 3rd or 4th decade
livedo reticularis
reticulated macular erythema of skin
lower extrem. most
cause by hypo perfusion of skin (exposure to cold environ)
leukocytoclastic vasculitis (LCV)
inflam of bl. vessels
caused by meds, infection, and autoimmune diseases
palpable purpura (red-purple domed papule) that don’t blanch w/ pressure
legs most
treatment is elim of cause
erosion vs ulcer
erosion = wound that affects epidermis only ulcer = affect epidermis and derm
phases of wound healing
- inflam: vasocon, clotting cascade, increased vascular perm (–> edema and pain), neutrophils and macrophages
- proliferative: fibroblasts stim ECM, angiogenesis, keratinocytes migrate and prolif
- maturation: wound contraction, inc. tensile strength, remodeling
pyogenic granuloma
rapid growing, friable vascular lesion that bleeds easily
often at site of trauma
prolif vascular tissue fails to reepithel. unless lesion is cauterized or surgically removed
scleroderma
acquired sclerosis (hypo cellular thickening of coll)
morphea (localized): expanding erthematous plaque that progressively becomes indurated
central hypopig, lilac ring
trunk most
not assoc w/ systemic disease
systemic:
-limited: face, distal extrem
CREST: Calcinosis cutis, Raynauds, Esophogeal dysmot, Sclerodactyly, Telangiectasis
-diffuse: trunk, prox extrem, cutan fibrosis, Raynauds, pulm fibrosis, renaul insuff, cardiac disease
poikiloderma of Civatte
combo of telangiectasias, hyper pigmentation, hypopigm, atrophy
common on neck and chest V
actinic purpura
minor trauma results in in focal bleeding
panniculitis
inflam disorder of subQ fat
tender, erythematous, non-ulcerated nodules w/ ill defined borders
lower extrem most
erythema nodosum (EN) is most common type
- delayed type hypersen rxn to antigenic stim
- inflam of fibrous septa
- causes: meds (pill), infections, sarcoidosis, IBD, idiopathic
treatment: elim cause, rest, compressions, elevation, NSAIDS
