Therapeutic Modalities and Wound Healing Flashcards
How do cells communicate?
Chemically (chemotaxis) and electrically (galvanotaxis - directional migration of cells to an electric field)
*increased bioelectric activity until the wound is closed
What does communication rely on?
Moisture
What does Senescence refer to?
Old, sluggish cells that do not respond well to communication or do not do their job in a timely fashion
*LACKS increased bioelectric activity until the wound is closed
What does estim do?
Reminds wound it should be in a state of repair
Encourages galvanotaxis; wound migration
Indications for e-stim? What are the benefits?
Encourage cell micgration to enhance a given healing phase
Increase angiogenesis and microvascular blood flow
Reduce local edema
? Possible reduction of BioBurden? (does not respond well to antibiotics)
Management of hematoma
Adjunct to topical wound management
Contradinications for estim?
Placement of electrodes:
- Tangential to the heart
- On patient with a cardiac pacemaker
- Along regions of the phrenic nerve
- Over the carotid sinus
- Over the laryngeal musculature
- In presence of malignancy in the wound base or periwound (don’t help bad cells divide)
- Over exposed bone with untreated osteomylitis (deal with infection first)
Most effective e-stim parameters?
High volt Pulsed Current (HVPC)
-Twin peak monophasic waveform
-High peak current which leads to deeper tissue penatration
-Unidirectional - DC
-Has not been shown to change tissue pH under electrodes or cause significant change in tissue temp as found with direct current (DC)
Mono or bipolar electrode placement
What should amps be for estim?
Amp should be 80-150V
What should duration be for estim?
30-60+ mins
3-7x week
(60 mins for 5-7x week shows big benefits)
-more feasible in home or IP setting; hard to get unit at home to rent
How to do monopolar technique?
Place saline-soaked gauze over the wound bed. Apply electrode over this and secure
How do you choose polarity for US? (to get fibroblasts/collagen moving)
Choose polarity based on evidence of studies and objective measures of wound progress (used to choose based on specific cell type desired)
Start with negative polarity and continue until it stalls, then go positive until it stalls, and so forth. Stop when there are no more gains
What is negative pressure wound therapy ?
Negative pressure or vacuum to open wound to facilitate healing
-place closed system on a dressing, then apply negative pressure
Looking for -125mmHg
Mechanisms of actions of NPWT?
Fluid balance/moist wound healing
Reduction in tissue edema
Mechanical deformation “cell Stretch” promotes cell proliferation and angiogenesis (wakes up cells, excites it, and spits out more protein)
SPEEDS WOUND CONTRACTION
Indications by diagnosis for NPWT?
Pressure ulcers (stage 3 and 4)
ORthopedic trauma wounds
Diabetic ulcers
Postoperative flaps, meshed graphs, bioengineered tissue graphs (Apligraf)
Open abdominal wounds
Surgically dehisced wounds (once closed, then opened again; likely due to infection or fluid build-up)
Partial-thickness burns
Indications by clinical presentation for NPWT?
Wounds with:
- Significant tissue deficit
- Exposed vital structures such as bone, tendon, or hardware
Mechanism to secure grafts and flaps as a bolus dressing
Reduce frequency of dressing change in the setting of copious drainage or pain
Contraindications for NPWT?
MALIGNANCY in the wound (address the ischemia first)
Untreated osteomyelitis!!
Exposed blood vessels, anastomotic sites, organs or nerves
Presence of more than 20% necrosis (negative pressure does not help w/ necrosis)
Non-enteric or unexplored fistula
Patients with bleeding disorders or inadequate hemostasis (or on blood thinners)
(tough to do in groin area and b/t toes due to all the moisture)
Wound prep before application with NPWT?
Perform complete wound exam
-Measure, identify structures, explore for sinus tracks, undermining, ensure periwound is appropriate for adhesives
Debride the wound
Initiate treatment for infection
Assess for adequate blood supply
Manage co-morbid/intrinsic/extrinsic factors
Safety w/ NPWT application?
Position pt and manage pain
Use NON-ADHERENT DRESSING in wound base for exposed bone, tendon, fascia, skin grafts, vascular structures
Protect the periwound skin
Avoid placement of drain or TRAC pad over bony prominence
VAC use WHITE foam in sinus tracts - esp in lower abs
DON’T USE BLACK FOAM BY EXPOSED BONES!
What is Hyperbaric Oxygen Therapy used for? (use of sub-atmospheric pressure to increased dissolved oxygen in plasma)
Collagen synthesis
Angiogenesis
Epithelialization
Management of bioburden
Wound Senescence may be related to wound hypoxia
What does TCOM (Transcutaneous Oxygen Mapping) measure?
It measures transcutaneous oxygen pressure of the wound
What is normal O2 pressure
60 mmHg at room air
Less than 30-40 is impaired wound healing
Vascular interventions for PAD should be completed prior to start of HBOT
What does HBOT do?
Increase the amount of O2 dissolved in plasma
- Induces neovascualrization of hypoxic tissue (O2)
- Improves leukocytes bactericidal function
- Increases fibroblast replication and collagen production (excites)
- Cumulative effect