Therapeutic drug monitoring

Question 1

Phenytoin

1. signs/ toxicity
2. signs under treatment
3. interactions and cautions
4. treatment

Answer 1

Inhibits voltage gated sodium channels

• axtaxia + nystagmus
• used to treat seizures
• as liver enzymes become sat > blood level rizes
• reduce dose/omit

Question 2

Digoxin

1. signs/ toxicity
2. signs under treatment
3. interactions and cautions
4. treatment

Answer 2

Inhibits Na/K/ATPase pump in heart > increase IC Ca2+

1. arrythmias, heart block, confusion, xanthopsia (seeing yellow)

Question 3

Lithium toxicity (4)

Answer 3

1. tremor
2. fits
3. arrythmia
4. renal fialure

Question 4

Gentamicin toxicity (4)

Answer 4

1. tinnitus
2. deafness
3. nystagmus
4. RF

Question 5

Theophylline toxicity (4)

Answer 5

1. arrythmias
2. anxiety
3. tremor
4. convulsions