LFTs

Question 1

Markers of liver cell damage (4)

Answer 1

1. ALT/AST
2. ALP
3. GGT
4. Br

Question 2

Markers of synthetic function (3)

Answer 2

1. INR
2. albumin
3. glucose

Question 3

AST/ALT (<40iu/L): raised due to hepatocyte death.

Give AST: ALT ratio in:

• alcohlic liver disease
• viral liver disease

Answer 3

1. 2:1
2. <1:1

Question 4

ALP (30-150 iu/L). Give 3 reasons for raised ALP

Answer 4

1. bone disease
2. Cholestasis
3. Pregnancy

Question 5

GGT (30-150 iu/L): 3 reasons for GGT elevation

Answer 5

1. chronic alcohol use
2. bile duct disease
3. metastasis

Used to confirm hepatic source of raised ALP