Therapeutic Drug Levels

Question 1

Amitriptyline

Answer 1

12-150 ng/mL

Question 2

Carbamazepine

Answer 2

4-12 mcg/mL

Question 3

Digoxin

Answer 3

0.8-2 ng/mL (non-HF: AFib)
05-0.9 (HF)

Question 4

Ethosuximide

Answer 4

40-100 ng/mL

Question 5

Gentamicin

Answer 5

Peak: 5-10 ng/mL
Trough: <2

Question 6

Lithium

Answer 6

Bipolar: 0.6-1
Acute mania: 0.8-1.2
Elderly: 0.4-0.8

Question 7

Nortriptyline

Answer 7

50-150

Question 8

Phenobarbital

Answer 8

10-40

Question 9

Phenytoin/Fosphenytoin

Answer 9

10-20

Question 10

Free Phenytoin

Answer 10

1-2.5 mcg/mL

Question 11

Primidone

Answer 11

5-12

Question 12

Procainamide

Answer 12

4-10 mcg/mL

Question 13

Tacrolimus

Answer 13

5-20

Question 14

Theophylline

Answer 14

5-15 mcg/mL

Question 15

Tobramycin (Traditional)

Answer 15

Peak: 5-10 mcg/mL
Trough: < 2 mcg/mL

Question 15

Valproic Acid

Answer 15

Total: 50-100
Mania: 50-125
Free: 60-22

Question 16

Valproic Acid

Answer 16

Total: 50-100
Mania: 50-125
Free: 60-22
Correct if albumin is low

Question 17

Vancomycin

Answer 17

Trough: 15-20 mcg/mL for most serious infections
Trough: 10-15 mcg/mL for others

Question 17

Warfarin

Answer 17

Goal INR: 2-3 for most indications; 205-3.5 if mechanical heart valve

Question 18

Warfarin

Answer 18

Goal INR: 2-3 for most indications; 205-3.5 if mechanical heart valve