Therapeutic Considerations Flashcards
What is a therapeutic consideration of raloxifene?
decreases breast cancer incidence?
What are the therapeutic considerations of bisphosphonates?
extended skeletal effects
unclear how to define overdosage
pamidronate and zoledronate are only available IV
IV dosage corrects hypercalcemia in days
How is denosumab administered?
subcutaneously every 6 months (osteoporosis) or monthly (malignancy)
How is salmon calcitonin administered and how long before it takes effect?
it is administered as a nasal spray or subcutaneously
subcutaneous doses lower blood calcium over hours
What are two experimental side effects of hPTH 1-34 and hPTH 1-84?
long term use caused osteosclerosis and osteosarcoma
What is a therapeutic consideration of aluminum hydroxide?
It is rarely used due to adverse effects
What is a therapeutic consideration of calcium carbonate?
acidic gastric pH is required for CaCO3 absorption
What is a therapeutic consideration of sevelamer?
lowers serum cholesterol by binding bile acids
What is a therapeutic consideration of calcitrol in comparison to other vitamin D analogues?
it may cause more hypercalcemia than either paricalcitol or doxercalciferol
Cinacalet is used off label to treat what?
other forms of secondary hyperparathyroidism
How is calcium carbonate administered?
It must be taken orally with food unless the patient is know to have normal gastric acid secretion
What is a therapeutic consideration of inorganic phosphates?
potassium phosphate is usually preferred over sodium phosphate to minimize renal excretion of phosphate and/or to correct coexisting hypokalemia
