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Pharmacology Chapter 31 > Mechanisms/Drug Class > Flashcards

Mechanisms/Drug Class Flashcards

1
Q

What is the mechanism of action of hormone replacement therapy?

A

Decrease bone resorption by osteoclasts

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2
Q

estrogen + progestin

A

hormone replacement therapy

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3
Q

What is the mechanism of action of selective receptor modulators (SERMs)?

A

Estrogen receptor agonist in bone, estrogen antagonist in endometrium and breast

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4
Q

raloxifene

A

SERM

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5
Q

What is the mechanism of action of bisphosphonates?

A

Decrease bone resorption by osteoclasts

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6
Q

alendronate

A

bisphosphonate

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7
Q

risedronate

A

bisphosphonate

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8
Q

ibandronate

A

bisphosphonate

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9
Q

pamidronate

A

bisphosphonate

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10
Q

zoledronate

A

bisphosphonate

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11
Q

What is the mechanism of action of RANKL antagonists?

A

Decrease bone resorption by osteoclasts

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12
Q

denosumab

A

RANKL antagonist

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13
Q

What is the mechanism of action of calcitonin?

A

Decrease bone resorption by osteoclasts

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14
Q

salmon calcitonin

A

calcitonin

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15
Q

What is the mechanism of action of bone anabolic agents?

A

Increase bone formation by osteoblasts

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16
Q

hPTH 1-34 (teriparatide)

A

bone anabolic agent

17
Q

hPTH 1-84

A

bone anabolic agent

18
Q

fluoride

A

bone anabolic agent

19
Q

What is the mechanism of action of oral phosphate binders?

A

Decrease GI absorption of dietary inorganic phosphate

20
Q

aluminum hydroxide

A

oral phosphate binder

21
Q

calcium carbonate

A

oral phosphate binder

22
Q

calcium acetate

A

oral phosphate binder

23
Q

sevelamer

A

oral phosphate binder

24
Q

What is the mechanism of action of vitamin D and analogues?

A

Increase GI absorption of dietary calcium, decrease transcription of PTH gene

25
Q

cholecalciferol (vit D3)

26
Q

ergocalciferol (vit D2)

27
Q

calcifediol (25(OH)D3)

A

vitamin D analogue

28
Q

calcitriol (1,23(OH)2D3)

A

vitamin D analogue

29
Q

doxercalciferol (1alpha-(OH)D2)

A

vitamin D analogue

30
Q

paricalcitol (19-nor-1,25(OH2)D2)

A

vitamin D analogue

31
Q

What is the mechanism of action of calcimmetics?

A

Increases sensitivity of calcium-sensing receptor to calcium in parathyroid cells, causes decreased secretion of PTH

32
Q

cinacalcet

A

calcimmetic

33
Q

What is the mechanism of action of calcium?

A

Essential for bone mineralization

34
Q

calcium gluconate

A

calcium (IV)

35
Q

calcium carbonate

A

calcium (oral)

36
Q

calcium citrate-malate

A

calcium (oral)

37
Q

What is the mechanism of action of inorganic phosphate?

A

Essential for bone mineralization

38
Q

potassium phosphate (pH 7)

A

inorganic phosphate

Pharmacology Chapter 31 (5 decks)

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