therap Flashcards
prolac sec adenoma dx
dopamine agonist - bromocriptine
bromocriptine action and ae
inhib rel of prolact
ae:
ctz - vomiting
mesolimbic - hallucinations
gh secreting tumour tx
surgery > radiotx
> octreotide- long acting somatostatin analog (normal ss is short acting)
cct secr tumours tx
surgery > radiotx (resistant)
>centrally acting - dec cct rel
periph acting - dec cortisol sec
gnt sec tumour tx
surgery > radiotx
> bromocriptine or octrotide
nonsec macroadenomas
surgery > radiotx
octreotide effective
h replacement for gh deficiency
somatotropin
h replacement for adh deficiency
desmopressin
drug treament options for graves
graves dx is antibods that stim tsh recp
either remove part of thyroid or
inhib thy hs synth with antithy dx
hyperthy tx
thy destruction: radioactive iodine - bad for preg cause passes placenta
antithy drugs- CARBIMAZOLE
carbimazole actions and ae
inhib thy h synth
ae- rash & granulocytosis (sore throat) this serious
breast feeding not rec as infant can be hypothy
thy crisis tx
beta blockers to inhib sympth
iodides - dec supply of thyroglob
carbimazole
hydrocortisone - protects from shock
hypothy tx
levothyroxine
liothyronine - rapid response for myxoedemic coma
drugs assoc with thy fx
amiodarone
lithium
interferon alpha
radiograph contrast
vit d activation pathway
vit d in liver becomes 2.5 hyd vit d
parathy h activates p450 in kidney to convert
2.5 hyd vit d > 1.25 dihyd vit d
active vit d function
incr rel and reabs of ca and ph
calcitonin
prevent reabs and movement of ca and ph
biphisphonates action
high affinity binding to bone and long lasting prevention of osteoclast activity
main mechanism for controlling plasma ldl
hepatic receptor mediated removal of ldl
statins action
hmg coa inhib
which inhib chol synth
simvist contraindic in preggy
fibrates eg bezafibrate action and ci
activates lipoprot lipase
ci renal or liver disease or failure
cholestytamine action and ci
bile sequestrant, binds to gut bile so red abs therefore inc chol excretion
ci in pud
used in preg
