therap

Question 1

prolac sec adenoma dx

Answer 1

dopamine agonist - bromocriptine

Question 2

bromocriptine action and ae

Answer 2

inhib rel of prolact
ae:
ctz - vomiting
mesolimbic - hallucinations

Question 3

gh secreting tumour tx

Answer 3

surgery > radiotx
> octreotide- long acting somatostatin analog (normal ss is short acting)

Question 4

cct secr tumours tx

Answer 4

surgery > radiotx (resistant)
>centrally acting - dec cct rel
periph acting - dec cortisol sec

Question 5

gnt sec tumour tx

Answer 5

surgery > radiotx
> bromocriptine or octrotide

Question 6

nonsec macroadenomas

Answer 6

surgery > radiotx
octreotide effective

Question 7

h replacement for gh deficiency

Answer 7

somatotropin

Question 8

h replacement for adh deficiency

Answer 8

desmopressin

Question 9

drug treament options for graves

Answer 9

graves dx is antibods that stim tsh recp

either remove part of thyroid or
inhib thy hs synth with antithy dx

Question 10

hyperthy tx

Answer 10

thy destruction: radioactive iodine - bad for preg cause passes placenta
antithy drugs- CARBIMAZOLE

Question 11

carbimazole actions and ae

Answer 11

inhib thy h synth

ae- rash & granulocytosis (sore throat) this serious

breast feeding not rec as infant can be hypothy

Question 12

thy crisis tx

Answer 12

beta blockers to inhib sympth
iodides - dec supply of thyroglob
carbimazole
hydrocortisone - protects from shock

Question 13

hypothy tx

Answer 13

levothyroxine
liothyronine - rapid response for myxoedemic coma

Question 14

drugs assoc with thy fx

Answer 14

amiodarone
lithium
interferon alpha
radiograph contrast

Question 15

vit d activation pathway

Answer 15

vit d in liver becomes 2.5 hyd vit d
parathy h activates p450 in kidney to convert
2.5 hyd vit d > 1.25 dihyd vit d

Question 16

active vit d function

Answer 16

incr rel and reabs of ca and ph

Question 17

calcitonin

Answer 17

prevent reabs and movement of ca and ph

Question 18

biphisphonates action

Answer 18

high affinity binding to bone and long lasting prevention of osteoclast activity

Question 19

main mechanism for controlling plasma ldl

Answer 19

hepatic receptor mediated removal of ldl

Question 20

statins action

Answer 20

hmg coa inhib
which inhib chol synth
simvist contraindic in preggy

Question 21

fibrates eg bezafibrate action and ci

Answer 21

activates lipoprot lipase
ci renal or liver disease or failure

Question 22

cholestytamine action and ci

Answer 22

bile sequestrant, binds to gut bile so red abs therefore inc chol excretion
ci in pud
used in preg