THEORIES OF AGING Flashcards
about the physiological processes that occurs to all organisms that age
BIOLOGIC THEORIES
Occurs randomly and accumulative overtime
STOCHASTIC
Aging is predetermined and timed phenomena
NONSTOCHASTIC
What are the 4 types of Stochastic theory
- Error Theory
- Free Radical Theory
- Cross-linkage Theory
- Wear and Tear Theory
- Originally proposed in 1963
- Errors in the transcription in the DNA causing enzyme or protein duplication as not exact compromising its functional ability.
ERROR THEORY
It is the byproduct of metabolism and can increase environmental pollutant.
This can accumulate and damage cell membrane.
Use of antioxidants to counter.
FREE RADICAL THEORY
Connective tissues or Glycosylation Theory
Proteins becomes tangles and will accumulate overtime causing tissue to not function optimally.
Can be prevented by dietary restrictions.
CROSS-LINKAGE THOERY
Proposed in 1882
Deterioration of cells due to overtime use.
WEAR AND TEAR THEORY
What are the 3 types of Nonstochastic Theories
- Programmed Theory
- Immunity Theory
- Gene/Biological Clock Theory
Cells have a certain number of times they can divide. Once it reached its limit, signs of aging will be evident.
Also known as “human fibroblast replicative senescence model”
PROGRAMMED (HAYFLICK LIMIT) THEORY
Diminution of the immune system cause by lower rate of T-cells.
This causes adults to be predisposed to diseases.
IMMUNITY THEORY
“Genetic control theory”
- Cells have genetically programmed aging
code stored in organism’s DNA
GENE / BIOLOGICAL CLOCK THEORY
Affects the hypothalamus and hormones in the body by decline or cessation.
NEUROENDOCRINE CONRTOL
Basic Metabolic Rate is directly affected by age. Organisms with higher metabolic rate will have a shorter lifespan.
METABOLIC THEORY OF AGING (CALORIC RESTRICTIONS)
The cells or mitochondrion will not produce the same level of energy. Also, as they deteriorate they may be harmful to our body.
MITOCHONDRIAL THEORY