Theophylline and Flex Review information Flashcards
1
Q
- MOA: competitive nonselective phosphodiesterase inhibitor, which raises intracelluar cAMP, activates PKA, inhibits TNF-alpha and inhibits leukotriene synthesis and reduces inflammation and innate immunity
- Additive maintenece therapy for poorly conrolled asthma using inhaled glucocorticoids
- primary maintenance for those using PO meds
- primary maintenance for those having difficulty with inhalors
- additive for those in ICU no responding to beta-2 agonist
A
Theophylline