Theme B: B2 Cells - B2.3 Cell Specialisation Flashcards
the development progression for humans
gametes –> zygote –> embryo –> foetus –> infant
gametes
the 2 cells that fuse together in sexual reproduction. Gametes are haploid sex cells (sperm in males and eggs in females) that carry half the genetic material of an organism.
zygote
A zygote is the diploid cell formed when two haploid gametes (sperm and egg) fuse during fertilization. It is the first stage of development in a multicellular organism.
cell differentiation
Cell differentiation is the process by which unspecialized cells, such as stem cells, develop into specialized cells with distinct structures and functions. This occurs through the selective expression of certain genes while others are suppressed.
after fertilization
how do cells intitially develop?
(in humans)
the zygote can divide very rapidly, and while the cells initially produced are unspecialised, the cells of the zygote also rapidly differentiate. this process results in the formation of specialised cells driven by the selective expression of certain genes while others remain inactive.
each cell will develop in a very specific manner depending on which genes become active and which signals the cell recieve.
cell signalling
the process by which infomrtaion is transferred from the cell surface to the nucleus. this is essential in controlling gene expression and thus differentiation.
morphogens
what are they? how does it effect the development of cells?
signal molecules that control cell differntiation. they occur in gradients (areas of concentration differences) in different regions of the early embryo.
the concentration of the signal molecules controls the regional development of teh first cells into head and tail structures.
the gradient of the signal molecules results in diffferent genes being expressed in different parts of the embryo. this leads different parts of the embryo to develop different structures.
as embryo develops, other signalling molecules become factors in differentitaion.
stem cells
population of cells within organisms that retain the ability to divide indefinetely and can differentiate along different pathways, resulting in all the cell types an organism possesses.
meristematic tissue
Where stem cells are contained in plants. it’s composed of rapidly reproducing cells that can form various types of tissue within the root or stem (a.k.a stem cells).
gardeners take advantage of these cells when they take cuttings from stems or roots and use them to grow new plants.
2 unique properties of stem cells
1) self renewal
2) recreate functional tissues
self renewal
when a stem cell divides, there are several possible outcomes:
1) both daughter cells remain stem cells
2) a stem cell and a differentiated cell may be formed
3) both cells differentiate
whatever the outcome is, the stem cells are maintained.
this process allows the continual production of a particular tissue whilse also providing for the continuation of stem cells.
stem cell niches
in a stem cell niche, the stem cells are present in high numbers due to regular proliferation.
e.g. bone marrow and hair follicles (in humans)
stem cell niches in humans are also studied in the contral nervous system, intestinal system, and in the muscle fibre bundles.
bone marrow
(as a stem cell niche)
stem cells that produce blood cells are found in the bone marrow alongside self renewing stem cells.
as blood cells are produced, differentiated cells are transported away via a large array of supporting blood vessels.
bone marrow tissue is multipotent.
the soft, spongy tissue that is in the medullary cavities (centers) of bones
hair follicles
as stem cell niches
they exist in the skin, and large numbers of epithelial stem cells are found in the bottom rounded area of a hair follicle. these stemc ells are multipotent.
these stem cells are also involved with hair growth, skin and hair follicle regeneration, and the production of sebaceous (oil-producing) glands associated with hair follicles.
a tube-like structure (pore) that surrounds the root and strand of a hair
what feature do all stem cell niches all have in common?
the presence of signalling factors that bring about both self renewal and differentiation.
types of stem cells
(in order of decreasing potency)
1) totipotent (total - most ‘potent’)
2) pluripotent (plural)
3) multipotent (multiple)
4) unipotent (one - least potent)
totipotent
- capable of continued dividiion and possesses the ability to produce any tissue in the organism.
- very few cells are totiptent.
- only exist in very early stages of embryo development.
- they may form a complete organism.
pluripotent
- arise form totipotent cells and only exist in early embryonic stage
- can mature into almost all the differnet cell types that exist in an organism
- unlike totipotent, they cannot produce a complete organism.
multipotent
- only forms limited number of cell types.
- bone marrow tissue is multipotent
- they occur later in the development of the embryo and present during the remainder of an organism’s life
unipotent
- only forms a single cell type, e.g. sperm cells in mammals
- usually form late in the embryonic stage and exist in the funcioning organism
one problem with using stem cells to treat disease
stem cells cannot be distinguished by appearance. they can only be isolated from other cells based on their behaviour.
therapuetic cloning
recent research directed towards growing large numbers of embryonic stem cells in culture so that they can be used to replace differentiated cells lost to injury or disease. this involves therapuetic cloning.
e.g.
* parkinsons and alzheimer diseases are caused by loss of proper functioning brain cells, where this technique could be used to replace these lost or defective brain cells, thus relieving symptoms.
* forms of diabetes
cell size according to various common cell types
red blood cell: 7.5
white blood cell: 12-15
sperm cell: 3 diameter, 50 length
skeletal muscle fibre: 10-50 width, 40 length
fat cell: 50-150
egg cell: 120
neuron (nerve cell): 350 length
all in micrometers
what is cell size determined by?
FUNCTION of a cell determines its size