Theme 3: Core Clinical Biochemistry

Question 1

Which tissues produce alkaline phosphatase?

Answer 1

Liver and bone

Question 2

Which class of drugs are used in the management of osteoporosis and can sometime result in osteonecrosis of the jaw?

Answer 2

Bisphosphonates

Question 3

Which cells are responsible for the breakdown of bone and are critical for its repair and maintenance?

Answer 3

Osteoclasts

Question 4

__?__ is a hereditary iron overload storage disease that can result in diabetes

Answer 4

Haemochromatosis

Question 5

Enlargement of thyroid with varying degrees of nodularity, where patients are mostly euthyroid

Answer 5

Multinodular goitre

Question 6

What is commonly measured to assess the degree of long term glycaemic control?

Answer 6

Glycated haemoglobin (HbA1c)

Question 7

__?__ is a catecholamine-secreting tumour arising from the adrenal medulla

Answer 7

Phaeochromocytoma

Question 8

What is the commonest thyroid cancer?

Answer 8

Papillary carcinoma

Question 9

What is the most common tumour arising from islets of Langerhans?

Answer 9

Insulinoma

Question 10

What is the main carrier of protein-bound calcium in the blood?

Answer 10

Albumin

Question 11

Which condition is a result of excess growth hormone during adulthood?

Answer 11

Acromegaly

Question 12

FSH-releasing factor is secreted by which gland?

Answer 12

Hypothalamus

Question 13

A T-score of less than -2.5 on a DEXA scan indicates which disease condition?

Answer 13

Osteoporosis