The Syndromes Flashcards
Name the syndromes (4)
Serotonin Syndrome
Anticholinergic “toxidrome”
Neuroleptic malignant (NM) syndrome
Malignant hyperthermia
Serotonin syndrome - medication history
Pro-serotinergic drug
Serotonin syndrome - time to develop
< 12 hr
Serotonin syndrome - vital signs
HTN
Tachycardia
Tachypnea
Hyperthermia (>41.1)
Serotonin syndrome - Pupils / Mucosa / Skin
Mydriasis
Sialorrhea
Diaphoresis
Serotonin syndrome - Bowel sounds
Hyperactive
Serotonin syndrome - Neuro-muscular tone
Increasesed (mostly lower limbs)
Serotonin syndrome - Neuro-muscular reflexes
Hyperreflexia
Clonus
Serotonin syndrome - Mental status
Agitation
Coma
Anticholinergic “toxidrome” - medication history
Anti-cholinergic agent
Anticholinergic “toxidrome” - time to develop
< 12 hr
Anticholinergic “toxidrome” - vital signs
HTN
Tachycardia
Tachypnea
Hyperthermia (<38.8)
Anticholinergic “toxidrome” - Pupils / Mucosa / Skin
Mydriasis
Dry Erythema
Hot and dry to touch
Anticholinergic “toxidrome” - bowel sounds
Decreased / Absent
Anticholinergic “toxidrome” - Neuro-muscular tone
Normal
Anticholinergic “toxidrome” - Neuro-muscular reflexes
Normal
Anticholinergic “toxidrome” - Mental status
Agitated delirium
NM syndrome - medication history
Dopamine antagonist
NM syndrome - time to develop
1-3 days
NM syndrome - Vital signs
HTN
Tachycardia
Tachypnea
Hyperthermia (>41.1)
NM syndrome - Pupils / Mucosa / Skin
Normal
Sialorrhea
Pallor, diahporesis
NM syndrome - Bowel sounds
Normal or decreased
NM syndrome - neuromuscular tone
“Lead pipe” rigidity
NM syndrome - neuromuscular reflexes
Bradyreflexia
NM syndrome - Mental status
Stupor, alert mutism, coma
Malignant hyperthermia - medication history
Inhalational anasthesia
Malignant hyperthermia - time to develop
30 min - 24 hr
Malignant hyperthermia - vital signs
HTN
Tachycardia
Tachypnea
Hyperthermia (up to 46)
Malignant hyperthermia - Pupils / Mucosa / Skin
Normal
Normal
Mottled appearance / diaphoresis
Malignant hyperthermia - Bowel sounds
Decreased
Malignant hyperthermia - Neuromuscular tone
Rigor mortis “like” rigidity
Malignant hyperthermia - Neuromuscular reflexes
Hyporeflexia
Malignant hyperthermia - mental status
Agitation
Serotonin syndrome Tx
Discontinue precipitating drugs
Supportive management
Serotonin antagonist - cyproheptadine
NM syndrome Tx
Discontinue precipitating drugs Supportive management Dopamine agonists (Bromocriptine >> Amantadine) Muscle relaxant (dantrolene) Lorazepam
Malignant Hyperthermia Tx
IV Dantrolene Correct metabolic acidosis Monitor serum potassium - insulin / glucose - calcium chloride or gluconate - IV lidocaine (arrhythmia) Cool to < 38 Maintain urinary output
Anticholinergic Toxidrome Tx
Cooling
Benzos
Physostigmine (CI w/ TCAs bc seizures)
-anti-cholinesterase agent
Cyproheptadine indication/MOA
Serotonin Syndrome
bromocriptine indication/MOA
Neuroleptic Malignant Syndrome
dantrolene indication/MOA
Neuroleptic Malignant Syndrome
physostigmine indication/MOA
Anti-ACh poisoning / anti-cholinesterase
amantadine indication/MOA
Parkisonian syndrome / DA releaser & enhancer (NMDA antagonist too)