Atypical antidepressants

Question 1

buproprion

Answer 1

DASNRI (mostly NE)
Seizure! Agitation, anxiety, restlessness
Smoking cessation

Question 2

duloxatine

Answer 2

SNRI 100x more potent than venlafaxine
Highly protein bound (95%)
CYP2D6 / CYP1A2
Half life - 12 hr

Question 3

venlafaxine

Answer 3

SNRI
Short half-life
Small, sustained HTN, sweating dizziness, nausea, anxiety
Half life 4-10 hr

Question 4

DASNRI

Answer 4

buproprion (mostly NE)

Question 5

trazadone

Answer 5

SARI
Tx depression w/ anxiety and sleep disturbances
Inhibit CYP3A4
Half life 2-9 hr

Question 6

SARIs

Answer 6

Trazadone, nefazadone, vilazadone

vortioxetine (also: 5-HT -1d, -3a, -7; +/-1b)

Question 7

mirtazepine

Answer 7

pre-synaptic alpha2 adrenergic antagonist (enhances release of NE and 5-HT)
Anti H - sedation
Weight gain
- 5-HT-2

Question 8

SNRIs (2)

Answer 8

duloxatine, venlafaxine

Question 9

alpha2 antagonist centrally acting

Answer 9

mirtazepine

Question 10

st john’s wort

Answer 10

Increases 5-HT and DA in CNS. Similar to SSRIs
photosensitizer, seratonin syndrome.
induces CYP3A4 & P-gp