the Stomach Flashcards
Blood supply to greater curvature
R and L gastroepiploic arteries
Blood supply to lesser curvature
R and L gastric arteries
Blood supply to pylorus
Gastroduodenal artery
Blood supply to fundus
short gastric arteries
Celiac trunk branches
see image
Parietal cells
Secrete HCl and intrinsic factor (needed for B12 absorption) into gastric lumen. Secrete bicarb into venous circulation and into protective gastric mucosa. Located in body and fundus
Chief cells
Secrete pepsinogen (digest protein). Located in fundus and body
G cells
Secrete gastrin. Located in antrum
Gastrin secreting cells are also found in duodenum and pancreas
Parietal cells are stimulated by what?
Gastrin, histamine, vagus nerve
What inhibits bicarb secretion into protective mucus by pareital cells?
NSAIDs, alpha blockers, alcohol, acetazolamide
What type of ulcer perforation will not show free air on KUB?
Posterior perf of duodenal ulcer = no free air because retroperitoneal
What is another complication of PUD besides bleeding or rupture?
Gastric outlet obstruction
Zollinger Ellison Syndrome
20% are associated with MEN1. Fasting serum gastrin > `1000 is diagnostic. Secretin stimulation test shows paradoxical rise in gastrin.
Preferred H. pylori tx
PPI, clarithromycin, amoxicillin x 14 days
Surgery for PUD, duodenal ulcer
Only if refrax to med tx or if hemorrhage/obstruction/perf. Can do highly selective vagotomy, taking out branches going to the lesser curvature of stomach.
Surgery for PUD, gastric ulcer
Depending on location: antrectomy, highly selective vagotomy, subtotal gastrectomy with R-enY
Early dumping syndrome (a postgastrectomy syndrome)
Within 15 min of eating- rapid emptying of food into small bowel. Food is hyperosmolar, so fluid rapidly shifts from plasma into the small bowel -> hypotension. Presents with pain, diarrhea, nausea, tachycardia. Manage by eating small frequent meals and avoid high sugar content foods. Usu resolves 7-12 weeks.
Late dumping syndrome (a postgastrectomy syndrome)
Hyperglycemia after meal -> insulin response -> hypoglycemia 2-3 hrs after meal. Present with dizziness, fatigue, diaphoresis, weakness. Tx is similar to early dumping syndrome.
Post vagotomy diarrhea
Usually self-limited, tx symptomatically e.g. with loperamide.