The Skin in Systemic Disease Flashcards by Daniel El-Dalil

What is the condition and what systemic illness is it associated with?

Ecthyma

Diabetes Meilltus

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What is the condition and what systemic illness is it associated with?

Pretibial Myxoedema

Hypothyroidism

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What is the condition and what systemic illness is it associated with?

Diabetic Dermopathy

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What is the condition and what systemic illness is it associated with?

Necrobiosis Lipodica

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What is the condition and what systemic illness is it associated with?

Tinea pedis

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What is the condition and what systemic illness is it associated with?

Necrobiosis Lipodica

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What is the condition and what systemic illness is it associated with?

Thyroid Acropathy

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What is the condition and what systemic illness is it associated with?

Neuropathic Ulcer

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What conditions are associated with thyroid?

Xerosis (dry skin)

Pruritis

Diffuse hair loss

Periorbital and facial oedema, pretibial myxoedema

Thyroid acropathy

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What skin changes do you get addisons and cushings?

Addisons: hyperpigmentation

Cushings: Striae

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What is the condition and what systemic illness is it associated with?

Eruptive Xanthoma

Hyperlipidaemia

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What is the condition and what systemic illness is it associated with?

Tuberous Xanthoma

Hyperlipidaemia

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What is the condition and what systemic illness is it associated with?

Tendinous Xanthoma

Hyperlipidaemia

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What is the condition and what systemic illness is it associated with?

Xanthelasma

Hyperlipidaemia

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What is the condition and what systemic illness is it associated with?

Dermatitis Herpetiformis

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What are the skin conditions associated with hepatic illness?

Jaundice

Pruritis

Spider naevi

Palmar erythema

What is the skin condition and the system it is related to?

Hereditary Haemorrhagic Telangiectasia

Gatroenterology

What group of conditions are these?

Vasculitis

What are the causes of vasculitis?

Connective Tissue Disease:

SLE

Rheumatoid

Wenger’s Granulomatosis

Infective Causes:

Meningococcal sepsis

Post Strep infection

Hepatitis C

Drugs

Cutaneous vasculitis

Describe the rash and name the condition?

D: localised to the face in photosensitive areas

C: butterfly configuration

M: erythematous macules

Systemic Lupus Erythematosus

What is the diagnosis and what are the causes?

Erythema Nodosum

IBD

Sarcoidosis

Inf: strep. TB

Drugs: Sulphonamides, OCP

Idiopathic

What is the following condition and what illnesses is associated with?

Pyoderma gangrenosum: note purpley tinge to the border

IBD

Myeloid diseases

Rheumatoid Artiritis

Diabetes

A patient comes in with proximal muscle weakness, teangiectasia in the nail folds and the following skin rashes/lesions, what is the diagnosis and what should be investigated for?

Dermatomyositis

25% of those will have an underlying malignancy,

Ovarian
Lung
Colorectal
Pancreatic
Hodgkin’s lymphoma

Note: rash on the upper eyelid is known as a heliotrope rash

Erythematous papules on the hand are known as Gottron;s papules

What is the follwoing condition, which regions does it commonly occur and what diseases is it related to?

Acanthosis Nigricans

Armpit, groin and neck

Gastric Adenocarcinoma

Diabetes

Obesity

The following condition is caused by a drug reaction, what is the condition, and which medications is it associated with?

Toxic Erythema Antibiotics and sulphonamides

The following condition is caused by a drug reaction, what is the condition, and which medications is it associated with?

Uticaria Salicylate and transiently after certain vaccines

What sort of reaction does the following image show?

A phototoxic reaction

Which medications can cause photosensitivity?

Tetracyclines Sulphonamides Amiadarone Furosemide Thiazide like diuretics Retinoids Nalidixic acid

What is the following condition and what other dematological conditions is it associated with?

Erythema Multiforme Associated with Steven Johnsons Syndrome and Toxic Endodermal Necrolysis

What is the following condition and where does it usually occur?

Steven Johnson Syndrome ## Footnote Mucosal sites May be severe eye and oral involvement Includes prodome of fever and respiratory symptoms

What is the following condition, what other symptoms will the patient have, what is the potential causative drug and what is the associated mortality?

Toxic Epidermal Necolysis Fever, Pain, Blistering and skin loss covering \>30% body surface area Mortality about 35% Causative drugs: NSAIDs, antibiotics, anticonvulsants

Which medications are the usual suspects in terms of skin eruptions?

Antibiotics (usually sulphonamides) Anticonvulsants NSAIDs Allopurinol

How would you manage a patient in skin failure e.g. Toxic epidermal necrolysis?

Stop causative agent. Refer to ITU and burns (high sepsis risk) Fluids Emollients and bandaging ENT and opthalmology review as there can be scarringh of mucosal sites.

What is the following condition and what conditions is it associated with?

Acquired Ichthyosis Asociated with malignancy