The Skin in Systemic Disease Flashcards
What is the condition and what systemic illness is it associated with?
Ecthyma
Diabetes Meilltus
What is the condition and what systemic illness is it associated with?
Pretibial Myxoedema
Hypothyroidism
What is the condition and what systemic illness is it associated with?
Diabetic Dermopathy
What is the condition and what systemic illness is it associated with?
Necrobiosis Lipodica
DM
What is the condition and what systemic illness is it associated with?
Tinea pedis
DM
What is the condition and what systemic illness is it associated with?
Necrobiosis Lipodica
DM
What is the condition and what systemic illness is it associated with?
Thyroid Acropathy
What is the condition and what systemic illness is it associated with?
Neuropathic Ulcer
What conditions are associated with thyroid?
Xerosis (dry skin)
Pruritis
Diffuse hair loss
Periorbital and facial oedema, pretibial myxoedema
Thyroid acropathy
What skin changes do you get addisons and cushings?
Addisons: hyperpigmentation
Cushings: Striae
What is the condition and what systemic illness is it associated with?
Eruptive Xanthoma
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Tuberous Xanthoma
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Tendinous Xanthoma
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Xanthelasma
Hyperlipidaemia
What is the condition and what systemic illness is it associated with?
Dermatitis Herpetiformis
What are the skin conditions associated with hepatic illness?
Jaundice
Pruritis
Spider naevi
Palmar erythema
What is the skin condition and the system it is related to?
Hereditary Haemorrhagic Telangiectasia
Gatroenterology
What group of conditions are these?
Vasculitis
What are the causes of vasculitis?
Connective Tissue Disease:
SLE
Rheumatoid
Wenger’s Granulomatosis
Infective Causes:
Meningococcal sepsis
Post Strep infection
Hepatitis C
Drugs
Cutaneous vasculitis
Describe the rash and name the condition?
D: localised to the face in photosensitive areas
C: butterfly configuration
M: erythematous macules
Systemic Lupus Erythematosus
What is the diagnosis and what are the causes?
Erythema Nodosum
IBD
Sarcoidosis
Inf: strep. TB
Drugs: Sulphonamides, OCP
Idiopathic
What is the following condition and what illnesses is associated with?
Pyoderma gangrenosum: note purpley tinge to the border
IBD
Myeloid diseases
Rheumatoid Artiritis
Diabetes
A patient comes in with proximal muscle weakness, teangiectasia in the nail folds and the following skin rashes/lesions, what is the diagnosis and what should be investigated for?
Dermatomyositis
25% of those will have an underlying malignancy,
- Ovarian
- Lung
- Colorectal
- Pancreatic
- Hodgkin’s lymphoma
Note: rash on the upper eyelid is known as a heliotrope rash
Erythematous papules on the hand are known as Gottron;s papules
What is the follwoing condition, which regions does it commonly occur and what diseases is it related to?
Acanthosis Nigricans
Armpit, groin and neck
Gastric Adenocarcinoma
Diabetes
Obesity
The following condition is caused by a drug reaction, what is the condition, and which medications is it associated with?
Toxic Erythema
Antibiotics and sulphonamides
The following condition is caused by a drug reaction, what is the condition, and which medications is it associated with?
Uticaria
Salicylate and transiently after certain vaccines
What sort of reaction does the following image show?
A phototoxic reaction
Which medications can cause photosensitivity?
Tetracyclines
Sulphonamides
Amiadarone
Furosemide
Thiazide like diuretics
Retinoids
Nalidixic acid
What is the following condition and what other dematological conditions is it associated with?
Erythema Multiforme
Associated with Steven Johnsons Syndrome and Toxic Endodermal Necrolysis
What is the following condition and where does it usually occur?
Steven Johnson Syndrome
Mucosal sites
May be severe eye and oral involvement
Includes prodome of fever and respiratory symptoms
What is the following condition, what other symptoms will the patient have, what is the potential causative drug and what is the associated mortality?
Toxic Epidermal Necolysis
Fever, Pain, Blistering and skin loss covering >30% body surface area
Mortality about 35%
Causative drugs: NSAIDs, antibiotics, anticonvulsants
Which medications are the usual suspects in terms of skin eruptions?
Antibiotics (usually sulphonamides)
Anticonvulsants
NSAIDs
Allopurinol
How would you manage a patient in skin failure e.g. Toxic epidermal necrolysis?
Stop causative agent.
Refer to ITU and burns (high sepsis risk)
Fluids
Emollients and bandaging
ENT and opthalmology review as there can be scarringh of mucosal sites.
What is the following condition and what conditions is it associated with?
Acquired Ichthyosis
Asociated with malignancy
