The Skeletal System Flashcards
Bone structure
A form of connective tissue
Consists of matrix in which cells are suspended
Functions of the Skeleton
Structural support Protect internal organs Provide leverage for movement Stores Ca Produces blood cells
Bone Structure - Matrix
- Organic component ( osteoid) made up of collagen and protein complexes. Strong, flexible but easily compressed.
- Inorganic component (hydroxyapatite) - deposition of mineral salts CaPO4 and CaCO3. Hard, inflexible and brittle.
Bone Structure - Cells
Osteoblasts - secrete osteoid and responsible for mineral deposition.
Osteogenic stem cells - found in endosteum and periosteum. Develop into osteoblasts
Osteocytes - mature bone cells, maintain the matrix; located in lacunae (nests).
Osteoclasts - remove minerals from the matrix, responsible for bone remodelling
Two Types of Bone Tissue
Compact bone
Cancellous bone - in the interior of the bone
Compact Bone
Basic functional unit is the Osteon (haversian system).
Osteons aligned in the same direction to increase unidirectional strength.
Circumferential lamellae (outside)
Canal of Volkmann
Interstitial lamellae (filling the gaps)
http://tle.westone.wa.gov.au/content/file/969144ed-0d3b-fa04-2e88-8b23de2a630c/1/human_bio_science_3b.zip/content/003_musculo_skeletal_support/page_05.htm
Osteon
Basic functional unit in compact bone Haversian canal Blood vessels Osteocytes in lacunae Canaliculli (little channels) Concentric lamellae
Cancellous Bone
Trabeculae of cancellous bone arranged haphazardly
Spaces between the trabeculae contain bone marrow
Bone Marrow
Found in spaces between the trabeculae of spongy bone and medullary cavities of long bones
Red bone marrow - myeloid tissue (haemopoietic)
Yellow bone marrow - fatty tissue that doesn’t produce blood. Can be transformed into red in anaemia.
Classification of Bones by Shape
Long bones - act as levers. Femur, metatarsals , phalanges.
Short bones - glide across one another. Carpals (wrist bones), tarsals (ankle bones).
Flat bones - protect organs, for muscle attachment. Sternum, scapula, pelvic, cranial.
Irregular bones - for muscle attachment. Vertebrae, some skull of bones.
Structure of long bone
Periosteum - outside Endosteum - inside Marrow cavity - middle Epiphysis (distal and proximal) Metaphysis Diaphysis
Bone Formation
Ossification or osteogenesis
Two methods:
1. Intramembranous
2. Endochondral
Intramembranous ossification
In flat bones and the clavicles
3 stages:
1. Mesenchymal cells secrete osteoid (organic component). Mesenchymal cells differentiate into osteoblasts. Deposition of Ca salts leads to calcification.
2. Blood vessels grow into area to supply nutrients and oxygen.
3. Initially only cancellous bones but remodelling occurs and compact bone developers.
Endochondral ossification
Inside +cartilage=endochondral
For long bones
1. Cartilage model laid down
2. Outer cells into osteoblasts, develops blood supply.
3. Cells in diaphysis differentiate into osteoblasts - primary ossification centre.
4. Osteoclasts erode centre of diaphysis - marrow cavity. It fills with fat.
5. Secondary ossification centres develop in the epiphyses and epiphyseal cartilage replaced by bone.
6. Thin plate of cartilage remains at the metaphysis - epiphyseal plate.
Bone Growth
Sex, growth and thyroid hormones stimulate bone growth.
1.New cartilage is laid at the epiphyseal side of the epiphyseal plate.
2. Osteoblasts invade the cartilage and replace with bone.
As long as the speed of cartilage growth exceeds the rate of osteoblast activity, the bone will grow in length.
3. When osteoblast activity increases and catches up with with cartilage formation, the epiphysel plate narrows and disappears - growth is halted.
Epiphysal line
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Bone remodelling
Ca salts are deposited and resorbed
Bone thickened in areas of increased strength
Injured bones replaced
Types of Fracture
Compound (open wound) or simple (closed) Greenstick - children Comminuted - lots of bone ends Linear - the same direction as bone Transverse - perpendicular Oblique - diagonal Spiral
Features of Synovial Joints
Fibrous capsule
Synovial membrane
Articular cartilage
Joint cavity containing synovial fluid
Bone Healing
- Haematoma formation.
- Area invaded by capillaries, fibroblasts, macrophages, osteoclasts & osteogenic cells. Soft callus.
- Soft callus hardened by mineral deposition (bony callus)
- Remodelling by osteoclasts
Takes 8 weeks. Good blood supply, no infections