The Senses Flashcards

1
Q

What is a sensory system?

A

A sensory system is a part of the nervous system responsible for processing sensory information.

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2
Q

What does a sensory system consist of?

A

Sensory receptors detect the signal that is around us.
Neural pathways transfer the signal from the sensory receptor up to the brain.
Brain areas that are activated by the sensory modality.

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3
Q

What is a sensation?

A

The process through which the senses pick up visual, auditory, and other sensory stimuli and transmit them to the brain; sensory information that has registered in the brain but has not been interpreted.

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4
Q

What is perception?

A

The process by which sensory information is actively organized and interpreted by the brain.

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5
Q

What are three common characteristics of all sensory processes?

A
  1. Apparence of adequate physical stimulus (respond to a certain type of stimulus and not others, each sensory system can only respond to a certain type of stimuli).
  2. Processes that convert information contained in physical stimulus into information encoded by neural signals (sensory processing needs to convert physical energy into AP’s).
  3. Apparence of specific body response to the message as conscious sense (perception) – conscious awareness of the stimuli in the environment.
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6
Q

What is transduction?

A

Process where the receptors change or convert the sensory stimulation into neural impulses.

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7
Q

Describe the steps of sensory processing.

A
  1. Sensory receptors collect the signal (note: each receptor is sensitive to special forms of physical energy, i.e., mechanical, thermal, chemical)
  2. Receptor is translating the energy of stimuli in electrochemical energy of receptor and action potentials –> transduction
  3. Signal transmitted to the brain
  4. Brain processing
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8
Q

What is a receptor potential?

A

Step between the arrival of energy at receptor cell and the initiation of an action potential.

It is usually an EPSP

If there is a stimulus with an energy that is strong enough, it will activate the receptor.

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9
Q

What is the role of a sensory receptor in sensory processing?

A

The structure of the receptor determines the form of energy to which it will respond. (what allows us to perceive the external environment) – the structure that allowed us to detect physical energy and then communicate the physical energy into our brain, think of it as a gate that allows us to see the external environment.

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10
Q

How many senses are there?

A
  • Vision
  • Hearing
  • Somatosensory (pressure, pain, temperature)
  • Vestibular sense (balance)
  • Proprioception (body movement)
  • Smell (olfaction)
  • Taste (gustation)
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11
Q

Explain the steps of visual processing?

A

The eye is the first step of visual processing, light goes into the eye and is reflected in the retina.
There are multiple layers in the retina which are the first step of our vision processing. If we zoom into the retina, we can see three different layers. In the final layer we can identify the visual receptor which are called cones and rods.
The visual receptor in the retina that are called rods allow us to process day and night vision and cones which allow us to process colour vision.
There is one type of rod for dark and bright light, and three different types of cones for colours.

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12
Q

What is the role of the visual receptors?

A

The eye captures light and focuses it on the visual receptors, which convert light energy to neural impulses sent to the brain.

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13
Q

Where are visual receptors located?

A

Visual receptors are in the retina.
• Four types of photoreceptors: 3 cones, 1 rod
• Rods –> for night vision
• Cones –> for colour vision

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14
Q

What is the structure of the retina?

A

Photoreceptor layer
Intermediate layer
Ganglion cells layer
(Light coming up from here)

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15
Q

What do rods and cones respond to?

A

• Rods and cones respond to light intensity

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16
Q

How do the photoreceptors work in darkness and light?

A

• In darkness, rods & cones constantly release a flow neurotransmitter (glutamate)
(Paradoxically they are activated and release neurotransmitter when there is darkness)

• When light is present it is absorbed by a pigment in rods and cones

• Causes change in shape of photopigment that triggers a G- protein cascade that reduces glutamate release
(This activates a G- protein, which is related to the transmission of a signal, this reduces the amount of neurotransmitter that is normally released)

• So, paradoxically, photoreceptors are inhibited (deactivated) by light!

To summarise there is a lot of the neurotransmitter in the dark but as soon as light reaches the eye, the production of the neurotransmitters is reduced. This allows us to perceive different intensities of light.

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17
Q

What cells does the intermediate layer of the retina contain and what is their role?

A

Contains bipolar, horizontal, and amacrine cells

Bipolar cells transfer information from rods & cones to retinal ganglion cells

Transforms light (brightness) information into contrast information

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18
Q

Explain the route of the vision pathway?

A

The light reaches the retina, then the signal crosses at the level of the optic chiasm and then it reaches the lateral geniculate nucleus of the thalamus and then the primary occipital cortex.
Information from the right eye goes into the left hemisphere and the information from the left eye goes into the right hemisphere.
They are crossing and transferring information to the opposite hemisphere.
What we see in the right eye is processed by the left occipital lobe and what we see in the left eye is processed by the right occipital lobe.
Before reaching the visual cortex, the signal reaches the lateral geniculate nucleus of the thalamus.

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19
Q

Briefly explain the vision pathway.

A
  • Eye
  • Retina
  • Thalamus
  • Lateral Geniculate Nucleus (LGN)
  • Primary Visual Cortex (striate cortex, V1)
  • Secondary Visual Cortex
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20
Q

Where is the thalamus located?

A

• In the Diencephalon, near the third ventricle.

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21
Q

What is the role of the thalamus in visual processing?

A

Sensory relay
• The thalamus relays sensory impulses from receptors in various parts of the body to the cerebral cortex.
• A sensory impulse travel from the receptors towards the thalamus.
• This signal is then passed onto the cerebral cortex for further processing.
• Recently been shown to process sensory information which is key to providing a perception of the environment. All sensory signals apart from smell and taste stop in the thalamus and then they go into the cortex

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22
Q

Summarise the vision pathway?

A

The eye contains the visual receptors which detects the signal and what type of signal it is (light or colour).
After the retina is the optic nerve, which is transferring information to the visual cortex, which is the final station, before the visual cortex is the chiasm where the nerves cross and then the thalamus which is our sensory relay. There are two visual cortexes’: V1 – the primary visual cortex which detects the key features of the signal and the secondary visual cortex which provides perception.

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23
Q

What is the role of the lateral geniculate nucleus (LGN)?

A
  • The lateral geniculate nucleus (LGN) is part of the thalamus and serves as the primary centre for processing visual information.
  • Relay station between eye and brain.
  • Response properties similar to retinal ganglion cells
  • But receives massive feedback from cortex – 10x as many connections as from the eye!
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24
Q

What happens in the visual primary visual cortex?

A
  • Information from the eye goes directly into this area.
  • The primary visual cortex detects the signal and can start recognising how a line is oriented, different types of colour and whether there is a type of frequency in the visual information.
  • It has a topographic organisation which is called a retinotopic map. This means your eye takes a picture of the external environment and then in the primary visual cortex, there is a retinotopic map of that picture and all the elements are already organised.
  • This allows us to interact easily with the environment and know where things are.
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25
Q

Where is the primary visual cortex located?

A

This is at the bottom of the brain in the occipital lobe and almost adjacent to the cerebellum.

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26
Q

What is the organisation of the primary visual cortex?

A

Topographic (retinotopic) organisation à contains a “map” of the visual field.
Detailed maps of orientation, colour, spatial scale, motion direction, 3D depth.

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27
Q

What does the primary cortex (V1) compute?

A

For each part of the visual scene, V1 computes: orientation, spatial frequency, motion, colour, depth

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28
Q

What happens in the extrastriate cortex?

A
  • After the primary visual cortex, there is further processing in the extrastriate cortex. (which is the secondary area in the brain for processing visual information).
  • Secondary cortical areas communicate to and from striatal cortex (V1)
  • Here the brain can build up a representation of the stimulus in terms of object recognition, location and motion, so it’s a much higher level of processing.
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29
Q

What is the most common type of receptors?

A

Somatosensory receptors are the most common receptors in the body because they are all around our skin.

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30
Q

What type of tactile receptors are there in somatosensory processing and what do they respond to?

A

Different type of tactile sensations: many different types of tactile receptors (mechanoreceptors)

Mechanical receptors respond to pressure on our skin and face. (Similar to how visual receptors respond to light.)

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31
Q

What two things define a mechanical receptor?

A

The receptive field and the stimulus response.

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32
Q

What is the receptive field?

A

The receptive field (RF) of an individual sensory neuron is the particular region of the sensory space in which a stimulus will modify the firing of that neuron

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33
Q

What is the stimulus response?

A

How the sensory receptor responds to the physical stimulus.

34
Q

What is the difference between fast vs slow adapting receptors?

A

In the fast-adapting receptor we can observe a response (AP) at the beginning when the stimulus is applied and at the very end when the stimulus is removed. The other receptor is firing all the time.

35
Q

What are the features of the Pacininian receptor?

A

A large receptive field and a fast-adapting response.

36
Q

What are the features of the Meissner receptor?

A

Meissner receptor: the receptive field is very small and is also fast adapting – meaning it can only respond at the beginning and the end of the stimulation.

37
Q

What are the features of the Merkel receptor?

A

It’s a slow adapting receptor with a small receptive field.

38
Q

What are the features of the Ruffini receptor?

A

It’s a slow adapting receptor with a large receptive field

39
Q

What does acuity mean?

A

A greater localisation of stimuli

40
Q

What kind of receptive field has greater acuity?

A

The smaller the receptive field, the better the acuity (the better the receptor is at detecting the signal in terms of spatial localisation)

41
Q

What tactile receptors have greater acuity?

A

Meissner and Merkel receptors have greater acuity. Their small receptive fields mean they have a greater acuity – a greater localisation of stimuli on our skin surface.

42
Q

What is mean two-point discrimination?

A

It determines the minimal distance at which someone can distinguish whether one or two points are in contact with the skin.

  • If there are two stimuli in both conditions, and the stimuli fall into two different receptors we can perceive them as two different entities.
  • If they don’t go into two different receptors and they reach the centre of one receptor instead, there is no way we can perceive them as two different entities – our brain will recognise only one.
43
Q

Explain (in detail) the somatosensory pathway.

A

We have the receptor on the skin and the information goes up into the spinal cord. In the spinal cord, the information goes into the somatic sensory nuclei that are on the dorsal horn. Each part of our skin surface is innervated by a specific nerve. There is perfect organisation. The part of the skin that is innervated by a specific nerve is called dermatome – the area that is supplied by a single nerve.

44
Q

What is a dermatome and how many do we have?

A
  • A dermatome is an area of skin that is mainly supplied by a single spinal nerve.
  • Although there are 31 pairs of spinal nerves in humans, there are only 30 dermatomes.
45
Q

Explain the somatosensory pathway briefly.

A
  • Mechanoreceptors (Skin)
  • Dorsal Column
  • Thalamus
  • Primary Somatosensory Cortex (S1)
  • Secondary Somatosensory Cortex (S2)
  • Associative Areas (Parietal lobe)
46
Q

How does the somatosensory cortex organise our body points and what is this called?

A

It systematically organises our body parts. Each part of the skin surface is represented by a specific region of primary somatosensory cortex = somatotopy

47
Q

What is the somatosensory homunculus?

A

The sensory homunculus is a distorted representation of the human body, based on a neurological “map” of the areas and proportions of the human brain dedicated to processing tactile signals for different parts of the body.

The area devoted to each body part in the model reflects the receptor density in that part.

48
Q

What receptors allow us to feel pain?

A

Nociceptors allow us to perceive painful stimuli.

49
Q

Discuss the types of nociceptors and what types of pain they trigger.

A

2 types of nociceptors, 2 types of fibers that are related to these nociceptors. They can trigger 2 different types of pain.
• Aδ fibers transmit information in a very fast way – it has a fast sharp, pinprick type of response.
• C fiber is a different type of pain as it builds up, it’s slower, dull and aching.

50
Q

Briefly explain the somatosensory pathway for path.

A
  • Nociceptors (Skin)
  • Dorsal Column
  • Thalamus
  • Primary Somatosensory Cortex (S1)
  • Secondary Somatosensory Cortex (S2)
  • Anterior Cingulate, Insula, Amyglada (a network called the pain matrix, which helps the processing of pain further)
51
Q

Briefly explain the somatosensory pathway for path.

A
  • Nociceptors (Skin)
  • Dorsal Column
  • Thalamus
  • Primary Somatosensory Cortex (S1)
  • Secondary Somatosensory Cortex (S2)
  • Anterior Cingulate, Insula, Amyglada (a network called the pain matrix, which helps the processing of pain further)
52
Q

What is the pain matrix and what does it process?

A

It involves a network of areas called the pain matrix including the Amygdala, anterior cingulate cortex, insular cortex.

They mediate perception of fear, anxiety, and unpleasantness of painful stimuli.

53
Q

What are the two different types of somatosensory processing for pain?

Why do we have this second stage of processing?

A

Sensory discriminative in the primary and secondary somatosensory cortices that are identifying the qualities of the painful stimulus.

Then there is another possible stage which is looking at all the emotions related to pain. We have this type of arrangement because pain is an important type of sensory information for survival. We need to make sure that as well as responding to the painful stimuli, we also have a very clear memory and very clear emotional responses related to that.

54
Q

What are pitch and loudness?

A

Pitch and loudness are signals transduced by auditory receptors

55
Q

What is frequency and what does a high and low frequency mean, in terms of what you would hear?

A
  • Frequency (=pitch) refers to the speed of vibrations
  • Rapid vibrations = high frequency = high pitch sound
  • Slow vibrations = low frequency = low pitch sound
56
Q

What is amplitude and what does a high and low amplitude mean, in terms of what you would hear?

A
  • Amplitude (=loudness) refers to the size of the vibrations
  • Large vibrations = high amplitude = loud sound
  • Small vibrations = low amplitude = quiet sound
57
Q

What is amplitude and what does a high and low amplitude mean, in terms of what you would hear?

A
  • Amplitude (=loudness) refers to the size of the vibrations
  • Large vibrations = high amplitude = loud sound
  • Small vibrations = low amplitude = quiet sound
58
Q

What is the anatomy of the ear divided into?

A

Divided into outer, middle, and inner ear

59
Q

What is the function of the outer ear (pinna)?

A

Amplifying sounds + determining the direction of a sound

60
Q

What is the function of the middle ear?

A

Tympanic membrane and ear bones –> also helps in amplifying the sound

61
Q

What is the function of the inner ear (cochlea)?

A

Organ of Corti –> Sensory organ for hearing (allows us to perceive sound – most important of the three components)

62
Q

What is the organ of cortisones and where is it located?

A

The Organ of Corti is the receptor for hearing and is located in the cochlea

63
Q

What are the sensory neurons of hearing and where are they located?

A

Hair cells are the sensory neurons of hearing –>the neurons that respond to sound vibrations.
The Organ of Corti includes hair cells (called cilia).

64
Q

How do vibrations caused by sound waved facilitate audition?

A

Vibrations caused by sound waves bend the stereocilia on these hair cells via an electromechanical force. The hair cells convert mechanical energy into electrical energy that is transmitted to the central nervous system via the auditory nerve to facilitate audition.
• Louder sounds move the stereocilia farther

65
Q

What kind of signal facilitates audition?

A

It works with a mechanical signal: When there is a sound, the hair starts to move, triggering the receptor and then the receptor transfers the action potential to the nerve and then up to the brain. It’s another type of mechanoreceptor (electro-mechanoreceptor).

(check in notes page 18)

66
Q

What is the hearing pathway?

A
  • Cochlea
  • Auditory (cochlear nerve)
  • Olivary Nucleus (brainstem)
  • Inferior Collicus
  • Medial Geniculate Nucleus (Thalamus)
  • Auditory Cortex
67
Q

Where is the sound information processed and where is this located?

A

Sound information is processed in the primary auditory cortex, located in the superior temporal lobe

68
Q

How is sound frequency organised in the Primary Auditory Cortex?

A

Like in the cochlea, each sound frequency is represented in a different location – tonotopy (perfect 1-to-1 correspondence with the cochlea and how the sounds are represented)

69
Q

What is processed in higher auditory areas?

A

Higher auditory areas (secondary) process complex sounds (e.g. speech)

70
Q

What two questions does the vestibular system answer?

A

Where am I?

Which way is up?

71
Q

What does your vestibular system tell your brain?

A

It tells your brain where your head is in 3D space and how you can move in order to interact with the environment. It’s already fully functional before birth.

Traditionally, the vestibular system is related to balance, gaze interaction and the perfect modal for multisensory interaction.

72
Q

Where is the vestibular system located and what are it’s two key components?

A

It’s located deep in our ear, in the temporal bone.

Two key components: the Semicircular Canals and Otiolith Organs

73
Q

What do semicircular canals detect and how do they do this?

A

They sense head rotations (angular acceleration)

Three different canals in one vestibular system, we have anterior, lateral and posterior in both ears and they work in a push and pull way.

So, if one vestibular organ is activated, the other is deactivated and vice versa.

In this perfect balance between activation and deactivation, our brain knows with a millisecond gap the acceleration of the movement of your head at all times.

74
Q

Briefly explain how semicircular canals can sense head rotations.

A
  • Semicircular canals filled with liquid (endolymph)
  • Rotation of head cause liquid to move opposite to rotation
  • This bends the jelly-like fluid, causing vestibular hair cells to bend and fire action potentials
  • Works by ‘Push & Pull’
75
Q

What do semicircular canals sense and how do they do this?

A

Sense linear acceleration (including gravity)

The otoliths are the only sensory receptors that can tell the brain about the direction and magnitude of gravity.

The hair cells covered in a fluid and the otoliths are tiny stones on top of the fluid. If your head is upright, the otoliths are perfectly balanced and don’t move. They can tell the brain that the head is upright and aligned with the gravitational direction.

When we move our head to the front, the fluid starts to shift which causes the tiny stones to also move and therefore the hair in the fluid starts to bend and this informs the brain, with an AP that your head is no longer upright and must be tilted.

76
Q

Briefly explain how otoliths can sense linear acceleration (including gravity).

A
  • The otoliths consist of hair cells embedded in a jelly-like substance, covered with heavy calcium carbonate crystals
  • Linear acceleration (e.g., tilting the head) cause the crystals to pull the gelatinous substance downward, bending hair cell stereocilia and causing depolarisation
77
Q

What is the vestibular system pathway?

A
  • Vestibular Receptors
  • Brainstem
  • (Cerebellum)
  • Thalamus
  • Vestibular areas
78
Q

What sensory pathway has no primary cortex?

A

There is no primary vestibular cortex

79
Q

What does the vestibular system have in its pathway instead of a primary cortex?

A

Vestibular network in the brain:
Somatosensory Cortex, Premotor Cortex, Anterior Insula, Posterior Parietal Cortex, Temporo-Parietal Junction (TPJ), Hippocampus

80
Q

What does the vestibular network in the brain do?

A

These areas are process vestibular information, there is a network that is spread all around our brain, it’s a completely different anatomical organisation to the other sensory modalities.