The Role of Neurones and Glia Flashcards
What is the nervous system composed of?
A network of neurons with supporting glia
What is the function of neurons in the nervous system?
They sense changes and communicate with other neurones
How many neurones are there in the central nervous system?
Around 1011
What is the function of glia in the central nervous system?
Support, nourish, and insulate neurones, and remove ‘waste’
How many glia are there in the CNS?
Around 1012
What are the types of glial cells?
- Astrocytes
- Oligodendrocytes
- Microglia
What is the most abundant type of glial cell?
Astrocytes
What is the role of astrocytes?
- Structural support
- Help to provide nutrition for neurones
- Remove neurotransmitters
- Maintain ionic environment
- Help to form the blood brain barrier
Where is the control of the concentration of neurotransmitters by astrocytes particularly important?
Glutamate
Why is the control of the concentration of glutamate particularly important?
Because it is toxic
How are astrocytes involved in maintaining an ionic environment?
K+ buffering
Why are astrocytes needed to help provide energy from neurones?
Because neurones do not store or produce glycogen
How do astrocytes help provide energy for neurones?
They produce lactate, which can be transferred to neurones via the glucose lactate shuttle, which supplements the neurones supply of glucose
What facilitates the astrocytes function of removing neurotransmitters?
They have transporters for transmitters, such as for glutamate
What can high levels of neuronal activity lead to?
A rise in [K+] in brain ECF