The Role of Neurones and Glia Flashcards

1
Q

What is the nervous system composed of?

A

A network of neurons with supporting glia

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2
Q

What is the function of neurons in the nervous system?

A

They sense changes and communicate with other neurones

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3
Q

How many neurones are there in the central nervous system?

A

Around 1011

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4
Q

What is the function of glia in the central nervous system?

A

Support, nourish, and insulate neurones, and remove ‘waste’

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5
Q

How many glia are there in the CNS?

A

Around 1012

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6
Q

What are the types of glial cells?

A
  • Astrocytes
  • Oligodendrocytes
  • Microglia
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7
Q

What is the most abundant type of glial cell?

A

Astrocytes

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8
Q

What is the role of astrocytes?

A
  • Structural support
  • Help to provide nutrition for neurones
  • Remove neurotransmitters
  • Maintain ionic environment
  • Help to form the blood brain barrier
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9
Q

Where is the control of the concentration of neurotransmitters by astrocytes particularly important?

A

Glutamate

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10
Q

Why is the control of the concentration of glutamate particularly important?

A

Because it is toxic

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11
Q

How are astrocytes involved in maintaining an ionic environment?

A

K+ buffering

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12
Q

Why are astrocytes needed to help provide energy from neurones?

A

Because neurones do not store or produce glycogen

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13
Q

How do astrocytes help provide energy for neurones?

A

They produce lactate, which can be transferred to neurones via the glucose lactate shuttle, which supplements the neurones supply of glucose

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14
Q

What facilitates the astrocytes function of removing neurotransmitters?

A

They have transporters for transmitters, such as for glutamate

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15
Q

What can high levels of neuronal activity lead to?

A

A rise in [K+] in brain ECF

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16
Q

What are oligodendrocytes responsible for?

A

Myelinating axons in the CNS

17
Q

What is responsible for myelinating axons in the PNS?

A

Schwann cells

18
Q

What kind of cells are microglia?

A

Immunocompetent cells

19
Q

How do microglia act as immunocompetent cells?

A

They recognise foregin material to activate, and them perform phagocytosis to remove debris and foreign material

20
Q

What is the function of the blood brain barrier?

A

It limits the diffusion of substances from the blood to the brain extracellular fluid, and maintains the correct environment for neurones

21
Q

Describe the structure of brain capillaries

A
  • Tight junctions between endothelial cells
  • Basement membrane surrounding the capillary
  • End feet of astrocyte processes
22
Q

What substances can be transported across the BBB?

A

Glucose, amino acids, and potassium

23
Q

What does the ability to transport certain substances across the BBB allow?

A

Allows for the concentration to be controlled

24
Q

In terms of transplant, what is the significance of the immune privileged status of the CNS?

A

It does not undergo rapid rejection of allografts

25
Q

Why is it important that inflammatory reactions do not occur in the CNS?

A

The rigid skull will not tolerate volume expansion, and so too much inflammatory response would be harmful

26
Q

How does the CNS prevent inflammatory responses from occuring?

A

The CNS inhibits the initiation of pro-inflammatory T-cell responses

27
Q

How is the CNS immune protected?

A
  • Microglia can act as antigen presenting cells
  • T-cells can enter the CNS
28
Q

Is the CNS isolated from the immune system?

A

No, immune privilege is not immune isolation, rather specialisation