"The Practice of Medicine 2 L29: Dyslipidemia Dx & Tx Kaushal B. Nanavati"

Question 1

What is the effect of hypothyroidism on cholesterol?

Answer 1

Increase in LDL and triglycerides

Question 2

What is the effect of type 2 DM on cholesterol?

Answer 2

Increase in triglycerides and decrease in HDL

Question 3

What is the effect of obesity on Cholesterol?

Answer 3

Increase in LDL and VLDL and decrease in HDL

Question 4

What is the effect of smoking on cholesterol?

Answer 4

Decrease in HDL

Question 5

What is the effect of choke static liver disease on cholesterol?

Answer 5

Increase in lipoprotein X

Question 6

What is the effect of nephrotic syndrome on cholesterol?

Answer 6

Increase in total cholesterol and LDL

Question 7

What is the effect of chronic kidney disease on cholesterol?

Answer 7

Increase in LDL and triglycerides

Question 8

What is the effect of weight loss as a treatment for cholesterolemia?

Answer 8

Increase in HDL and decrease in LDL when done in a healthy manner

Question 9

Station medications are similar to what lifestyle modification responsible for lowering cholesterol?

Answer 9

The Mediterranean diet

Question 10

T/F: Smoking cessation shows benefits at reducing cholesterol that far exceed pharmaceutical intervention.

Answer 10

True

Question 11

What is the cardiovascular risk reduction when taking statins?

Answer 11

20-30% regardless of baseline LDL

Question 12

Class: Evolocumab

Answer 12

PCSK9 inhibitor

Question 13

Class: Alirocumab

Answer 13

PCSK9 inhibitors

Question 14

What step so statins inhibit in the cholesterol synthesis pathway?

Answer 14

HMG-CoA –> Mevalonate

Question 15

Garlic has been shown to be as effective at reducing cholesterol as:

Answer 15

Bezafibrate

Question 16

What is he Framingham Eisk Calculator?

Answer 16

Calculates risk of having a heart attack or dying from HD within 10 years

Inputs age, systolic BP, total chol, HDL, on HTN meds, cigarette smoker, diabetes present

Screening starts at age 40 in men, 50 in women

Question 17

What is the standard of care for low risk Framingham patients,

Answer 17

Retest in 5 years with risk estimation

Question 18

What is the standard of care for Framingham moderate risk patients, 10-19% per year?

Answer 18

Discuss initiation of moderate intensity statin

Question 19

What is the standard of care for a Framingham high risk patient,

Answer 19

Discuss initiation of a high intensity statin

Question 20

Are statins recommended during pregnancy and breastfeeding?

Answer 20

No

Question 21

There is a continuous, positive, relation between plasma cholesterol and what complication?

Answer 21

Six year coronary heart risk