"Microbiology and Immunology Urinary Tract Infections Rebecca Greenblatt"

Question 1

T/F: Enterobacteriaceae and Enterococci are less pathogenic than E. coli in causing UTI, but just as antibiotic-resistant.

Answer 1

True

Question 2

Besides E. Coli, what gram negative organisms commonly cause UTI?

Answer 2

Shigella
Salmonella
–the enterobacteriacae

Question 3

What opportunistic pathogens can cause UTI?

Answer 3

Klebsiella/Enterobacter/Serratia and Proteus/Providencia/Morganella

Atypical UTIs are opportunists; sequels of urinary tract procedures/catheters, diabetes, or sepsis.

Question 4

What is the effect of Enterobacteriaceae being promiscuous to incorporating foreign DNA?

Answer 4

Rapid acquisition of virulence factors and antibiotic resistance. –> UTI

Question 5

What is the major virulence factor of uropathogenic E. Coli?

Answer 5

Factor P (type 1) fimbrae attach to uroepithelial cells and work their way up the urethra

Question 6

What is one major complication of Klebsiella infection in alcoholic men?

Answer 6

In addition to UTIs, encapsulated K can cause dangerous hemorrhagic pneumonia in alcoholic men

Question 7

T/F: Enterobacter can become “panresistant.”

Answer 7

True

Question 8

Serratia is one cause of what complication in heroin addicts?

Answer 8

Endocarditis

Question 9

Proteus/Providencia/Morganella can cause struvite stones using what virulence factor?

Answer 9

Urease

Question 10

How is cystitis treated?

Answer 10

In uncomplicated UTI, treat with sulfa drug or fluoroquinolone