The Oral Cavity, Esophagus, And Stomach Chapter 16 - Dr. Dobson

Question 1

Erythroplakia

Answer 1

red velvet in oral cavity

= dysplasia , precancerous

Question 2

Leukoplakia

Answer 2

white not able to scrape off in oral cavity, 25% precancerous

Question 3

SCC genes

Answer 3

TP53, CDK2A, PIK3CA, FAT1, NOTCH1

Question 4

HPV proteins

Answer 4

E6 —-I P53

E7 —-I P16

Question 5

Olser-Weber Rendu disease :

Answer 5

AD affects BVs , tendency to bleed, light led dots on tongue and lips
= Hereditary Hemorrhagic Telengiectasia

Question 6

test for HSV

Answer 6

Tzanker Test

Question 7

Torus Palatinous

Answer 7

bony outgrowth in oral cavity

Question 8

Pyogenic granuloma

Answer 8

inflammatory lesion gingiva of children and pregnant women

= can becone peripheral ossifying fibroma

Question 9

2 important things you see in SCC

Answer 9

1. keratin pearl

2. intracellular bridges

Question 10

where is it secreated

1. Salivary amylase
2. lingual lipase

Answer 10

1. parotid gland

2. submucosa layer of the tongue

Question 11

the bigger the salivary gland

Answer 11

the more likely it is benign tumor there

Question 12

Pleomorphic adenomas

Answer 12

PLAG1 and HMGA2 gene

Question 13

Warthin tumor

Answer 13

2nd most common salivary neoplasm (pleomorphic is most common)
= in parotid gland
= secreats chemotracactants for lymphoid cells

Question 14

Mucoepidermoid carcinoma :

Answer 14

minor salivary glands more : and parotid gland, malignant, 11:19 translocation, MECT1-MAML2

Question 15

psuedomyxoma peritonei

Answer 15

intraperitoneal tumor of mucinous asites (especially starting in the appendix

Question 16

key step happening in developing diffuse gastric cancer

Answer 16

loss of E-Cadherin

Question 17

MALToma translocations

Answer 17

11: 18

Question 18

Well differentiated neuroendocrine carcinoma (carcinoid tumor)

Answer 18

jejunum and ilieum

Question 19

GIST

Answer 19

most common mesenchymal tumor of the abdomen interstitial cell Cajal
= carney syndrome + carney stratakis –> Neurofibromatosis type 1

Question 20

Tylosis

Answer 20

RHBDF2 mutation : Howel Evans syndrome
yellow dry scaling skin on palms and feet
- seen in HIV and maybe HPV
- risk for SCC