the never-remember tiny molecules

Question 1

Primary biliary cholangitis, look for ____ abs?

Answer 1

anti-mitochondrial antibodies
(fibrosis of intrahepatic bile ducts)

Question 2

Cirrhosis and emphysema?

Answer 2

alpha-1 antitrypsin deficiency

Question 3

Type 1 autoimmune hepatitis ab?

Answer 3

anti-smooth muscle abs
anti-nucular abs

Question 4

wilson’s disease test?

Answer 4

Ceruloplasmin levels

(liver and neuro sx: hepatosplenomegally, elevated AST/ALT, depression, movement disorder)

Question 5

Hemocromacytosis test?

Answer 5

ferritin and transferin saturation
(liver disease, hyperpigmentation, diabetes, cardiomyopathy)

Question 6

Thrombotic thrombocytopenic purpura

Answer 6

autoantibodies against ADAMTS13

(ADAMTS13 then can’t cleave Von Wilabrand, VW then traps and activates platelets)

Question 7

Mixed cryoglobulinemia syndrome
Molecule & sx

Answer 7

Serum cryoglobulin levels
Rheumatoid factor
hypocomplementemia

palpable purpura, weakness, arthralgias, peripheral neuropathy

Question 8

Ankalosing Spondylitis

Answer 8

HLA-B 27

(absent ANA or RF)

Question 9

Polymyositis abs?

Answer 9

anti-nuclear ab
anti-Jo-1

Definitive dx is muscle biopsy

Question 10

Sjogren’s syndrome?

Answer 10

Anti-Ro/SSA and anti-La/SSB abs

Question 11

Celiac disease?

Answer 11

Anti-tissue transglutaminase ab
Anti-endomysial ab

Question 12

Systemic sclerosis?

Answer 12

Anti-topoisomerase

Question 13

Cutaneous Sclerosis

Answer 13

Anti-centromere abs