The Kidneys in systemic disease Flashcards
1
Q
Why is the kidney a particular target for many systemic diseases?
A
The kidney receives more blood flow per unit volume than any other organ in the body
The glomeruli may filter proteins which are then reabsorbed by the tubule epithelial cells
The glomeruli may trap proteins or immune complexes
The kidney metabolises or excretes certain drugs, which may be toxic to the kidney
2
Q
Which systemic diseases can affect the kidney
A
DM
Cardiovascular - cardiac failure, hypertension, atheroembolism, atherosclerosis
Infection - sepsis, post-infectious GN, infective endocarditis
Inflammation in blood vessels - Lupus, vasculitis, scleroderma, cryoglobulinaemia
Myeloma
Amyloidosis
Drugs - NSAIDs, aminoglycosides, ACE inhibitors
