Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Urinary clinical conditions > The Kidney In Systemic Disease > Flashcards

The Kidney In Systemic Disease Flashcards

1
Q

What 2 main clinical signs are indicative of diabetic nephropathy?

A

slowly progressing Proteinuria

Decline of GFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the main indicative factor for development of diabetic nephropathy?

A

Prolonged hyperglycaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What percent of patients with diabetic nephropathy will develop end stage renal failure?

A

30%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is vasculitis?

A

Inflammation within the walls of any vessel in the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What determines the type of vasculitis?

A

Defined by the size of vessel involved

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where in the body does Wegeners granulomatosis mostly affect?

A

Respiratory tract & kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the presentation of wegeners granulomatosis in the kidneys?

A

Focal necrotising glomerulonephritis with crescents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the difference betwen microscopic polyarteritis and wegeners?

A

Wegeners affects respiratory tract, kidneys and other systems in the body whereas microscopic polyarteritis is more localised to the renal system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is an important diagnostic test in vasculitis?

A

Immunostaining of P-ANCA and C-ANCA
Or
ELISA for anti-myeloperoxidase (C-ANCA) and Porteinase 3 (P-ANCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which anti body corrolates to wegeners and which one to microscopic polyarteritis?

A 
Wegeners = C-ANCA
M.P = P-ANCA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the downfall of ANCA testing in immunostaining?

A

False positive in conditions such as IBD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What kidney condition can infective endocarditis cause?

A

Glomerulonephritis +/- small vessel vasculitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

In infective endocarditis, what would suggest that there is renal involvement?

A

Abnormal urea/creatinine
Haematuria, red cell casts
Reduced complement levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is multiple myeloma?

A

Monoclonal proliferation of plasma cells in bone marrow producing an excess of immunoglobulins and light chains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the clinical signs of renal failure in myeloma?

A 
Cast nephropathy 
Light chain nephropathy
Amyloidosis
Hypercalcaemia
Hyperuricaemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is amyloidosis?

A

Deposition of abnormal fibrillary proteins that persist

17
Q

In what condition is amyloidosis found?

A

Multiple myeloma

18
Q

What is the clinical presentation of multiple myeloma?

A 
Markedly elevated ESR
Anaemia
Weight loss
Fractures
Infections
Back pain / cord compression
19
Q

When would you suspect that the systemic disease is causing the renal impairment?

A

Signs and symptoms of systemic presentations along with abnormal urinalysis +/- impaired renal function

Urinary clinical conditions (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions