The Immune Sustem Flashcards

1
Q

Define: Immunity

A

Protection from infectious diseases

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2
Q

Define: Immunology

A

Ye study of immunity and the cellular / molecular events after their contact with foreign molecules

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3
Q

Define: immune system

A

Coordinated response by the immune system against foreign substances

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4
Q

Define: immunisation

A

Induction of immunity by vaccination

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5
Q

In order for the immune system to function, what are the main tasks it must fulfil

A

Recognition
Containment
Regulation
Memory

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6
Q

During recognition, the immune system must…

A

Recognise the presence of a pathogen. This is mediated through white blood cells and lymphocytes.

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7
Q

During containment the immune system must…

A

Contain (or better) the infection to prevent it spreading. This is mediated by complement system, phagocytosis and destruction by lymphocytes.

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8
Q

During regulation the immune system must…

A

Self regulate to avoid damage to the body

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9
Q

What happens is regulation of the immune system is out of control

A

Allergies

Autoimmmune diseases

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10
Q

Why is memory important in the immune system

A

Once exposed to an infectious agent, the immune system system must be able to set an immediate and strong response quickly

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11
Q

What are the 4 main features of the immune system

A

Specificity
Memory
Diversity
Self discrimination

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12
Q

What is specificity

A

Each response is unique to a particular antigenic determinant er epitope. For each determinant a specific lymphocyte will be induced

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13
Q

What is memory

A

Learns or remembers past experiences - memory lymphocytes stimulated by secondary response produce specific lymphocyte against antigen

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14
Q

What is diversity

A

Able to act against many different organisms due to its a bailout to distinguish subtle differences in structure

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15
Q

Wha is self discrimination

A

Distinguish self from non-self. Imbalance leading to auto-immune diseases

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16
Q

Where do all virus’s act

A

Intracellularly

17
Q

Where do most parasites and bacteria act

A

Extra cellular

18
Q

Name an intracellular arctic parasite and bacteria

A

Malaria, Tuberculosis

19
Q

What is an antigen

A

Substance that can trigger or generate an immune response

Almost anything can be an antigen

20
Q

What is a hapten

A

Simple organic substances that can be recognised by the immune system but cannot trigger an immune response. These only trigger a response when bound to a carrier

Penicillin is highly reactive, when it enters the body it binds to proteins creating a complex which the body does not recognise causing an immune response

21
Q

What features of a bacterial cell wall distinguish it from an animal cell

A

Proteins, polysaccharides, peptidoglycan

22
Q

Where to cells of the immune system come from

A

Exclusively marrow in adults

Liver during foetal development

23
Q

What are pluripotent cells

A

Cells from which all other immune cells can differentiate, found in the bone marrow

24
Q

What 2 streams can pluripotent cells differentiate into

A

Myeloid and lymphoid

25
Q

Give examples of myeloid cells

A

Dendritic, mast, monocytes, macrophages

26
Q

Give examples of lymphoid cells

A

T- cells, B-cells, Natural Killer cells

27
Q

What forms the innate immune system

A

Myeloid cells - (dendritic, mast, macrophage, monocytes, basophils)

28
Q

What forms adaptive immune system

A

Lymphoid cells (T-cells, B-cells, NK-cells)

29
Q

What causes differentiation of these stem cells

A

Cytokines and cell-cell interactions