The Genome and its Transmission Flashcards

1
Q

What is the transcriptome?

A

The complete set of RNA transcripts.

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2
Q

What is the proteome?

A

The complete set of proteins produced.

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3
Q

List 4 examples of RNA that are not translated into proteins.

A

1 & 2 - rRNA and tRNA are involved in the translation of mRNA.

3 - snRNA is involved in modifying other RNA molecules.

4 - miRNA binds to mRNA to inhibit translation.

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4
Q

What is satellite DNA?

A

Repeated sequences of nucleotides.

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5
Q

What type of DNA is found at centromeres?

A

Heterochromatin containing satellite DNA.

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6
Q

List 2 differences between heterochromatin and euchromatin.

A

1 - Euchromatin is transcriptionally active whereas heterochromatin is not.

2 - Heterochromatin stains darker than euchromatin.

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7
Q

What is the function of telomeres?

A

To protect the end of the chromosome from deterioration or from fusion with neighboring chromosomes.

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8
Q

List 3 roles of repeated sequences of DNA.

A

1 - Formation of telomeres.

2 - Formation of centromeres.

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9
Q

At which stage of mitosis does chromatin condensation begin?

A

Prophase.

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10
Q

At which stage of mitosis does spindle assemble outside the nucleus?

A

Prophase.

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11
Q

What is a kinetochore?

A

The section of the centromere to which microtubules of the spindle attach.

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12
Q

What is a nucleolus?

When are they present?

A
  • The site of rRNA transcription in the nucleus.

- They appear during interphase and reappear at telophase.

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13
Q

What mediates cytokinesis?

A

A contractile ring of actin and myosin.

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14
Q

What are chiasmata?

A

The point on a bivalent at which crossing over and exchange of genetic material occur.

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15
Q

List 4 sources of variation.

A

1 - Mutation.

2 - Random mating.

3 - Random fertilization.

4 - Crossing over between chromatids of homologous chromosomes during meiosis.

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16
Q

What is a bivalent?

A

A pair of homologous chromosomes.

17
Q

List 3 differences between meiosis I and meiosis II.

A

1 - In meiosis I, homologous chromosomes separate, while in meiosis II, sister chromatids separate.

2 - Genetic recombination (crossing over) only occurs in meiosis I.

18
Q

What is the name of the male gamete stem cell?

A

Spermatogonium.

19
Q

What is a zygote?

A

A fertilised ovum.

20
Q

What is a polar body?

A

A small haploid cell that is formed at the same time as an egg cell during oogenesis, but which does not have the ability to be fertilized.

21
Q

How might repeated sequences lead to genetic diseases?

A
  • Through slipped mispairing:

- One section of the repeat sequence ‘slips’ to bind to complementary bases further / earlier down the sequence.