The Endocrine Pancreas Flashcards
1
Q
Pancreatic Acini
A
secrete enzymes active in protein, fat and carbo digestion (typsin, lipase, amylase)
2
Q
alpha a cells
A
glucagon
3
Q
beta B cells
A
insulin and amylin
4
Q
delta d cells
A
somatostatin
5
Q
epsilon e cells
A
gherkin
6
Q
PP f cells
A
pancreatic polypeptide
7
Q
what are the main functions of the endocrine pancreas
A
- control of blood glucose in absorptive and post-absorptive states (insulin and glucagon)
- stimulate/inhibit enzymes and HCO3- secretion in GI tract
8
Q
how is insulin made
A
- transcription of insulin gene
- mRNA encoding preproinsulin
- translation of preproinsulin
- signal sequence is cleaved and disulphide bond is formed in the ER
- converting enzymes and cleavage of c peptide in the Golgi
- matter insulin is in secretory granule
