The Digestive System - Lower Gastrointestinal Tract Flashcards
Diverticula
Sac like protrusion of the colonic mucosa through the muscular wall
Which part of the GIT does diverticula disease affect the most
Sigmoid colon
Diverticulosis
Presence of asymptomatic diverticula
Diverticular disease
Symptomatic diverticula (e.g. abdo pain) in the absence of infl (can be used as umbrella term)
Diverticulitis
Symptomatic a/c infl and infection of diverticula
Epidemiology of diverticulosis
Increases w/ age, affects up to 80% at 85
Lifetime risk of a/c diverticulitis 4-25%
Risk factors for diverticular disease
Diet - red meat, low fibre
obesity
Fhx
Smoking
Meds - NSAIDs, steroids
Pathophys of diverticular disease
Colonic mucosa protrudes through muscualris externa, only covered by serosa
Occurs in weak areas, related to increased intra-liminal pressure and abnormal colonic motility
Clinical features of diverticulitis
Abdo pain - LLQ/ LIF
Pyrexia
CIBH
Guarding/ peritonism
Tachycardia
Ix of diverticular disease
CT CAP - best for dx
Bloods
Classification of diverticulitis
Used to help guid need for surgical intervention
Ranges from confined pericolic infl to generalised faecal peritonitis
Out pt mx for a/c diverticulitis
For mild, uncomplicated disease
7-10 days of co-amoxiclav
Analgesia - avoid NSAIDs and opiates
Reassess after 2/7 and arrange colorectal clinic appt
What alternative abx can be used in diverticulitis
Cipro
Metronidazole
Why should NSAIDs and opiates be avoided in diverticular disease
Risk of perforation
In-pt mx of divertiuclitis
Admit pts who are elderly, co-morbid, unwell and peritonitis
If features of severe infection - sepsis 6
Commence IV abx and should be NBM
What should be advised for pts if diverticula disease
Start high-fibre diet
Complications of diverticula
Fistula
Colic stricture
Diverticular bleed
Imaging of SBO
Can see central stacked bowel loops >3.5cm but usually <6cm in diameter
Markings cross lumen diameter
Paucity of gas in large bowel
Pathologies causing SBO
Adhesions and bands
Hernia
Crohn’s disease
Infiltrating neoplasms
Intussecption
Intussusception
Piece of small bowel slides onto adjacent part of the Intestine
Typically, a paediatric dx, v concerning in adults (used by large polyps)
Imaging of large bowel obstruction
Peripheral air-filled loops >7cm in diameter
Haustra do not cross lumen diameter
Does dilated large bowel obstruction always cause SBO
Depends on competency of ileocoecal valve
Classification bowel obstruction
No fluid or gas is able to pass beyond the site of obstruction
Partial/ incomplete bowel obstruction
Some fluid or gas is able to pass beyond the site of obstruction
Mechanical bowel obstruction
Physical blockage to the flow of GI content
Non-mechanical bowel obstruction (ileus)
Obstruction to flow 2’ to neuromuscular dysfunction (e.g failure in peristaltic activity)
Closed loop bowel obstruction
The bowel is obstructed at two points, this prevents proximal or distal decompression os contents
High-risk of rapid necrosis and perforation
Causes of large bowel obstruction
Tumours
Volvulus
Diverticular strictures
Key positive finding in bowel obstruction
Raised lactate - indicator of ischaemia
Raised infl markers
3, 6, 9 rule in bowel obstruction
Dilatation of the small bowel >3cm, large bowel > 6cm or the caecum > 9cm is suggestive of abnormal dilatation
Supportive mx of bowel obstruction
Drip and suck - IV fluid and NGT insertion (aspiration)
Analgesia
Anti-emetic
Abx as needed
Correction of electrolytes
Surgery for bowel obstruction
Defunctioning stoma and resection - observe lesions
Adhesiolysis +/- bowel resections
Role of appendix in diarrhoea
May serves as bacterial reservoir to repopulate enteric bacteria following illness
Unique colonic anatomy
Taeniae coli
Haustra
Epiploic appendages
Taeniae colic
There bands of smooth muscle that make up longitudinal muscle layer of muscularis, except at terminal end
Haustrae
Contraction of taemia coli bunch up
Causes of wrinkled appearance of colon
Epiploic appendages
Small, fat-filled sacs of visceral peritoneum
Attached to taenia colic
Recta valves
3 lateral bends in rectum
Separate faeces from gas to prevent simultaneous passage of faeces and gas
Differences in internal and external anal sphincter
Internal - made of smooth muscle, involuntary contractions
External - skeletal muscle, voluntary contractions
Anal sinuses
Depression between anal columns that’s secrete mucous to facilitate defectaion
Dentate line
Horizontal, jagged line that runs below anal sinuses
Represents junction between hindgut and external skin
Why is the area below the dentate line more sensitive than the area above
Due to innervation by somatic sensory fibres vs visceral, sensory fibres
Role of goblet cells in anal mucosa
Ease movement of faeces
Protects intensive from the effects of the acids and gases produced by enteric bacteria
How does immune system in healthy gut work
Peptidoglycan activates release of cytokines by mucosal epithelial cells, drafting immune cells e.g. dendritic cells
Dendritic cells becomes APCs and travel to lymphoid follicles to trigger an IgA-mediated response
How does fibre optimise activities of the colon
Softens stool
Increases power of colonic contractions
Mechanical digestion of large intestine
When chyme moves from ileum into caecum (ileocecal sphincter)
When caecum is distended w/ chyme, contraction of sphincter strengthen
When a hausturm is distended w/ chyme, its muscle contracts, pushing residue into next haustrum
How does chemical digestion occur in the large intestine
No digestive enzymes so done by bacteria
What is flatulence
Excessive flatus
Composition of faeces
Undigested food residue
Unabsorbed digested substance
Millions of bacteria
Old epithelial cells
Inorganic slats
Water to let it pass smoothly out of the body
What is defecation
Mass movement forces faeces from the colon into the rectum, scratching rectal wall and provoking defecation reflex
Defecation reflex
Parasympathetic reflex
Contracts sigmoid colon , rectum and eternal anal sphincter, relaxes internal
Faeces in anal canal triggers signal, allowing you to choose to open external anal sphincter
If you delay defecation, takes a few secs to relax
What happens if defection is delayed an extended time
Addn water is absorbed, making faeces firmer —> constipation
Dysentery
Severe diarrhoea w. blood or mucous
Blood test findings for IBD
Anaemia
Thrombocytosis
Rased ESR and CRP
Hypoalbuminaemia
Raised fecal calprotectin
Infective ddx for IBD
Gastroenteritis/ dysentrey
C diff
Amoebiasis
TB
CMV
Histoplasmosis
Non-infective ddx for IBD
Appendicitis
Diverticulitis
Carcinoma
Ischaemic colitis
Endometriosis
Indications of aminosalicylates
Indication of remission in active UC (not CD)
Maintenance of remission in uC (not CD)
Post-op prophylaxis in CD
Smoking
Mesalazine
Thiopurines
Metronidasole 3/12
(Biologics)
Episcleritis in IBD
Asymptomatic to itching and barring
Treat IBD and use steroid drops
Uveitis and IBD
Px w/ eye pain, blurred vision, photophobia
Doesn’t correlate w/ IBD activity
Treat w/ topical/ systemic steroids
Erythema noduosum and IBD
Seen in 15% of IBD pts
Mirrors IBD activity
Treat IBD and use steroids
Lower GI motility symptoms
Diarrhoea
Constipation
Definition of diarrhoea
Passage of loose/ watery stool, typically 3x/ day
Reduced consistency/ increased freq
Time period for diarrhoea - definitions
A/c - 14 days or less
Persistent - 15-30 days
C/c - 30+ days
What causes increased water content of stool in diarrhoea
Impaired water absorption and/or
Active water secretion by the bowel
What is a/c diarrhoea usually due to
Infections - viral, bacterial, protozoal
Drugs
Osmotic diarrhoea - pathophys
Water is drawn into or retained in the bowel due to presence of solutes within the lumen due to indigestion of poorly absorbed solutes or malabsorption
What type of diarrhoea can be reduced by fasting
Osmotic
Causes of secretory diarrhoea
Bacterial endotoxin
Stimulant laxatives
Hormones
Bile acid malabsorption
Mucosal infl
Rectal villous adenoma
Secretory diarrhoea
Disruption of epithelial electrolyte transport so water build up
Treatment of diarrhoea
Treat underlying disorder
Opiates
Anti-secretory drugs - octreotide (SST analogue)
Opiates for diarrhoea
Decreases urgency, bowel freq and stool volume
Codeine phosphate, loperamide
U&E’s changes w/ diarrhoea
Low potassium
Urea increases, before creatinine
Definition of constipation
Slow colonic transit, impaired rectal emptying or both
3x/day - 3x/ week
Treatment of constipation
General measure
Bulk forming laxatives
General measure for constipation
Identify anatomical abnormalities
Identify biochem causes
Stop constipating drugs
Exercise
Increase fluid intake
Increase dietary fibre - (SE: bloating, flatulence)
What are bulk forming laxative used for
Mild constipation
Improves bowel freq rather than consistency / straining
Examples of bulk forming laxatives
Ispaghula
Sterculia