The Citric Acid Cycle Flashcards
where does TCA cycle take place?
the matrix of the mitochondria
when is the majority of ATP formed?
during oxidative phosphorylation
what is the entry point of TCA cycle?
acetyl CoA reacting with oxaloacetate
what are the two parts of oxidative phosphorylation?
the electron transport chain and the synthesis of ATP
what is the electron transport chain constructed from?
a number of multi-protein complexes where each protein has a number of co-factors essential for their function.
what is the final acceptor of the ETC?
oxygen - which is converted to water
how are the components of the ETC organised?
in order of oxidative power
what happens as electrons pass through the ETC complex ?
energy is released and protons are pumped into the inter-membrane space increasing the H+ concentration lowering the pH.
when is the proton gradient formed during TCA cycle/
when the H+ ions move into the inter-membrane space
what is chemiosmosis?
when hydrogen ions move from the inter-membrane space, through ATPsynthase, allowing the reaction of ADP to ATP.
describe the shape of ATP synthase
part is embedded in the matrix and part in the membrane. the internal rod runs from top of the molecule down to the bottom, through the centre. the catalytic knob is in the matrix.
what is the catalytic knob?
part of the molecule ATP synthase that is responsible for the formation of ATP
what is oxidative phosphorylation?
the process by which ATP is formed by the transfer of electrons from NADH.
how does the catalytic knob control the synthesis of ATP?
the H+ ions move through the top of the molecule causing it to rotate, this drives the rotation of the internal rod causing conformational changes in the catalytic knob.
how many ATP are formed by the oxidation of NADH
3
