The Cell Cycle and Cancer - The liver as an exemplar Flashcards
1
Q
What phosphorylates PIP2 –> PIP3?
A
P13-K
2
Q
What does the phosphorylation of PIP2 activate?
A
PDk1 + PKB/Akt
3
Q
What is PTEN?
A
a PIP3 phosphatase
4
Q
What do FOXO transcription factors transcribe?
A
-ve cell cycle regulators –> p27Kip, FAS ligand
5
Q
When does p27Kip promote the cell cycle?
A
when it is bound to cdk4 + cyclin D
AND
when it is unphosphorylated
6
Q
What is p27Kip promoted by?
A
GSK3B
7
Q
What is p27Kip inhibited by?
A
PkB/Akt
8
Q
How is active cdk4/cyclinD maintained?
A
P13-kinase pathway promotes cell cycle progression by inactivated G3k3B
9
Q
What is p53?
A
TSG
10
Q
What are the three main functions of p53?
A
activates DNA repair proteins
induces growth arrest
initiates apoptosis
11
Q
Give some examples of kinases that activate p53
A
MAP kinase
ATR
ATM
