thalassemia Flashcards
1
Q
Hemoglobin H
A
_ _ / _ a
2
Q
Cooley’s anemia
A
2 severely abnormal or absent Beta genes
(beta thalassemia major)
always tranfusion dependent
3
Q
HbE
A
structurally abnormal hemoglobin due to point mutation in beta globin gene
26glu–>lys
4
Q
HbEE
Degree worse or better than
HbEBo thalassemia?
A
better
only mild and does not need transfusion whereas HbEBo is severe and needs transfusion
5
Q
shape of thalassemia cells?
A
mexican hat because excess of RBC membrane despite smaller size
cross section look like targets
6
Q
Barts?
A
4 gamma chains when bambino has alpha thalassemia
7
Q
Hemoglobin H
A
4 beta chains -
post-fetal alpha thalassemia
