TH1, TH2, Treg cells, TH17

Question 1

signature cytokine for TH1 and what other cytokines does it secrete

Answer 1

ignature cytokine: IFN-gamma

secretes IL-2 and IL-3

Question 2

function of IL-2

Answer 2

enhances NK cells
memory T cell production
drives dendritic cells and macrophages to secrete IL*12
activates CTLs precursors

Question 3

function of IFN-gamma

Answer 3

drives B cell to produce IgG2 and IgG3

activates macrophages and complement

Question 4

signature cytokine for TH2 and what other cytokines does it secrete

Answer 4

ignature cytokine is IL-4

secretes IL-3, IL-4, IL-5, IL-10, IL-13

Question 5

function of IL-4 and IL-13

Answer 5

drives IgM switch to IgE

drives IgG4 production which neutralises antibodies

Question 6

function of IL-5

Answer 6

involved in eosinophil development

IgA production for mucosal immunity

Question 7

function of IL-10

Answer 7

immunosupresses TH1 cells

inhibits the production of IL-12

Question 8

Treg cells and signature cytokine with functions

Answer 8

Secretes TGF-beta(signature cytokine), IL-4 and IL-10
it is an immunosuppressant and helps in tumour growth
maintains peripheral tolerance to self antigen- controlling factor in autoimmunity

Question 9

Th17, functions and signature cytokines

Answer 9

secretes TH17 but has no signature cytokine

involved in inflammation (neutrophil accumulation)