Factor I, C4 binding protein, C1 inhibitor, DAF, MCP

Question 1

what is factor I

Answer 1

protease

Question 2

what cofactors can be used for Factor I

Answer 2

MCP, factor H, C4 binding protein and Complement receptor 1

Question 3

function of factor I

Answer 3

blocks formation of C3 and C5 convertase

cleaves to C3b, C3(H2O), C4b and C4(H2O)

Question 4

function of C4 binding protein

Answer 4

prevents C3 convertase formation by binding to C4b and so displacing C2a
it is a cofactor for factor I

Question 5

what is a C1 inhibitor and what complement pathway does it affect

Answer 5

C1 inhibitor is a protease

affects the complement pathway and lectin pathway

Question 6

how does C1 work

Answer 6

irreversibly binds to activated C1 and MBL subunits

Question 7

function of DAF

Answer 7

prevents C3 and C5 convertases by binding to C4b in classical pathway and C3b in alternative pathway

Question 8

function of MCP

Answer 8

Cofactor for factor I

controls amplification loop

Question 9

function of CD59

Answer 9

prevents MAC attack at C( binding step

Question 10

function of Complement receptor 1

Answer 10

decay of C3 and C5 convertases

expressed in leukocytes, RBC, neutrophil and monocytes

Question 11

f

Answer 11

g