TFTs

Question 1

rise in ALT is a sign of

Answer 1

hepatocellular injury

Question 2

rise in ALP is a sign of

Answer 2

cholestasis

Question 3

hepatocellular injury is suggested by

Answer 3

• ALT ++ by > 10 fold

- ALP ++ by <3 fold

Question 4

cholestasis is suggested by

Answer 4

• ALT ++ by <10 fold

- ALP ++ by >3 fold

Question 5

raised ALP & GGT suggests

Answer 5

• cholestasis
• alcohol
• drugs (phenytoin)

Question 6

isolated rise in ALP

Answer 6

bone problems

Question 7

jaundice but normal ALT/ALP suggest

Answer 7

pre-hepatic causes of jaundice

Question 8

Ix to assess synthetic liver function

Answer 8

• serum bilirubin
• serum albumin
• prothrombin time (PT)
• serum blood glucose

Question 9

how to differentiate between conjugated and unconjugated hyperbilirubinaemia

Answer 9

conjugated causes darker urine since conjugated bilirubin is urine-soluble

Question 10

normal urine + normal stools = what type of jaundice?

Answer 10

pre-hepatic

Question 11

dark urine + normal stools = what type of jaundice?

Answer 11

hepatic

Question 12

dark urine + pale stools = what type of jaundice?

Answer 12

post-hepatic

Question 13

ALT>AST is associated with?

Answer 13

chronic liver disease

Question 14

AST>ALT is associated with

Answer 14

• cirrhosis

- acute alcoholic hepatitis

Question 15

bilirubin is markedly elevated in

Answer 15

cholestasis