test 9 Flashcards

1
Q

Our continued health depends on the body’s

ability

A

• To deliver the appropriate amount of oxygen to
each cell
• For each cell to uptake and consume the proper
amount of oxygen

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2
Q

Normal Oxygen Consumption

A

200-250 mL O2/min

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3
Q

What is the final common

pathway of all causes of death

A

tissue hypoxia

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4
Q

energy production is determined by what

A

metabolic rate

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5
Q

creation of energy is supported by what

A

adequate amounts of glucose and oxygen delivered to the cells

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6
Q

similarities between aerobic and anaerobic metabolism

A
  • both start with glucose metabolized to pyruvate

- both produce ATP

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7
Q

Aerobic metabolism

A

-O2 present
• Pyruvate converted to acetyl-CoA, which enters the Krebs cycle
which produces carbon dioxide, water and ATP
• 1 mole glucose→ 36 moles ATP
-end product= CO2 and H2O

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8
Q

Anaerobic metabolism

A

• Pyruvate converted to lactic acid and ATP
• 1 mole glucose→ 2 moles ATP
-end product= lactic acid

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9
Q

monitoring what can tell you a lot about what has occurred during your pump run

A

lactate

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10
Q

why measure lactic acid in blood

A

-if lactic acid present, we know that there are areas in our body where anaerobic metabolism has occurred

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11
Q

Arterial O2 content

A

17-20 mL/100mL blood

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12
Q

Venous O2 content

A

12-15 mL/100mL blood

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13
Q

A-V O2 difference

A

4-6 mL/100mL blood

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14
Q

what is one of the best ways to increase O2 content

A

-increase hemaglobin

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15
Q

O2 delivery (& normal value)

A
  • DO2 = Arterial content × Cardiac output
  • 950-1150 mL O2/min
  • Indexed: 550-650 mL O2/min/m2
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16
Q

O2 reserve

A

• The amount of oxygen left AFTER consumption
has taken place
• Venous gases returning to the heart
• A built-in physiologic buffer (in case we need it)

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17
Q

Normal Oxygen Reserve

A
  • 700-800 mL O2/min

- Indexed: 450 mL O2/min/m2

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18
Q

How long can you use your reserve

A
  • around 32% SvO2

- then anaerobic metabolism starts to come into play

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19
Q

Factors That Increase Oxygen Consumption

A
  • Patient conditions
  • Medications
  • Procedures
20
Q

Patient Conditions that Increase Oxygen Consumption

A
  • Minor surgery: 7% increase
  • Fever (each 1 o C): 10%
  • Agitation: 16%
  • Increased work of breathing: 40%
  • Severe infection: 60%
  • Chest trauma: 60%
  • Shivering: 50 to 100%
  • Sepsis: 50 to 100%
21
Q

Medications that Increase Oxygen Consumption

A
  • sympathetic agonists

- causing an increase in CO and vasoconstriction

22
Q

Procedures that Increase Oxygen Consumption

A
  • Dressing change: 10% increase
  • Physical examination: 20%
  • Visitors: 22%
  • Endotracheal suctioning: 27%
  • Turning: 31%
  • Chest physiotherapy: 35%
  • Nasal intubation: 25 to 40%
23
Q

Factors that Decrease Oxygen Consumption

A
  • Hypothermia (7oC): 50% decrease
  • Morphine sulfate IV: 21%
  • Anesthesia: 25%
  • Assist/control ventilation: 30%
  • Neuromuscular blocking agents
24
Q

Ischemic hypoxia

A

• Inadequate blood flow (regional or general)
• Obstructive lesions of blood vessels
-(Coronary or cerebral thrombosis or spasm or Peripheral vascular disease)

25
Q

Hypoxemic hypoxia

A
  • Inadequate transfer of oxygen from the lungs to the hemoglobin molecule
  • Hypoxemia most common cause, Carbon monoxide poisoning, Methemoglobinemia
26
Q

Anemic hypoxia

A

-Deficiency of hemoglobin molecules

27
Q

Toxic hypoxia

A
  • Inability of body cells to uptake or use oxygen

- Sepsis, cyanide toxicity, and ethanol toxicity

28
Q

Excessive tissue requirements

A
  • Oxygen demand higher than system can supply

- Hypermetabolism, Sepsis, alcohol withdrawal, extreme fever

29
Q

Impaired oxygen unloading

A
  • At the capillary level

- alkalemia, hypocarbia, and Administration of large amounts of banked blood

30
Q

Compensatory Mechanisms for Impaired Tissue Oxygenation

A
  1. Increase cardiac output (primary response)
  2. Draw from venous reserve
  3. Polycythemia
31
Q

Increase cardiac output (primary response)

A

• The tissues control the cardiac output in accordance with their
need for oxygen
• Healthy heart can increase to 15-25 L/min
-acute response

32
Q

Draw from venous reserve

A

• Extract more oxygen from hemoglobin
• Can decrease venous sat to 32% before anaerobic metabolism starts
-acute response

33
Q

Polycythemia

A

• Increase amount of hemoglobin and RBC mass
• Takes weeks to develop
-long term response

34
Q

Monitoring Oxygen Transport

A
  • Arterial and mixed venous blood gas (central lab)
  • Point-of-care blood gas
  • Noninvasive pulse oximetry
  • Invasive mixed venous saturation
  • Continuous indwelling arterial blood gas
  • Transcutaneous measurement of local tissue saturation
35
Q

Arterial and Mixed Venous Blood Gases from Central Lab

A
  • Lag time between sampling and results
  • Intermittently performed
  • May not detect acute, severe hypoxemia
36
Q

Point-of-Care Blood Gas Analyzers

A

-bedside blood gas

37
Q

Point-of-Care Blood Gas Analyzers pros

A
• Able to measure gases, electrolytes, glucose, lactate, urea, nitrogen
and hematocrit
• Small and portable
• Small blood volume required
• Self-calibrating
• Disposable cartridges
38
Q

Point-of-Care Blood Gas Analyzers cons

A

• Can be expensive with labor intensive quality control

39
Q

Noninvasive Pulse Oximetry

A

• 2 light emitting diodes (LED) send red and infrared
light through the arterial vascular bed
• Photodetector measures transmitted light and
detects the relative amount of color absorbed by
arterial blood and estimates the saturation
• Saturated Hb= Absorbs more infrared light
• Desaturated Hb= Absorbs more red light
-can be placed on the patient’s finger, toe, earlobe or nose bridge
• Accuracy: ± 4%
• less reliable with saturations between 50 and 70%
• no accuracy below 50%
• Adequate peripheral perfusion required

40
Q

Noninvasive pulse oximetry does NOT

A

-guarantee that oxygen is being delivered to or used by the cells

41
Q

Falsely ↓ Saturation Values for Pulse Oximetry

A
  • Nail polish/acrylic nails
  • Dark skin pigmentation
  • IV dyes
  • Lipid infusions
  • Anemia (Hct < 10%)
  • Venous pulses
  • Patient movement
42
Q

Falsely ↑ Saturation Values Pulse Oximetry

A
  • Elevated carboxyhemoglobin
  • Elevated methemoglobin
  • Intense surgical light
43
Q

SpO2 Ranges

A
  • 96-99% : Normal
  • 85-90% : Mild tissue hypoxia
  • 75-85% : Significant widespread tissue hypoxia
44
Q

Invasive Mixed Venous Saturation

A

• Measured via fiberoptic pulmonary artery
catheter
• Uses reflectance spectrophotometry

45
Q

Invasive Mixed Venous Saturation: General Info

A

• very fragile so you don’t want to break them or bend/kink
• Manufacturer specific pre-insertion calibration
required and in vivo calibration
• Keep catheter tip away from the wall of the
pulmonary artery (reflection from the vessel will distort results)
• Not able to distinguish carboxyhemoglobin and
methemoglobin from oxyhemoglobin

46
Q

Continuous Indwelling Arterial and Venous Gases

A
  • can measure saturation through tubing of pump
  • can take continuous blood gasses of samples
  • calibrate with tanks of gas
47
Q

Transcutaneous Measurement of Local Tissue Saturation

A
  • near-infrared spectrometry (NIRS)
    • Uses specific, calibrated wavelengths of nearinfrared
    light
    • light is absorbed relative to amount of oxygen attached
    to the hemoglobin in the blood vessels