test 9 Flashcards
Our continued health depends on the body’s
ability
• To deliver the appropriate amount of oxygen to
each cell
• For each cell to uptake and consume the proper
amount of oxygen
Normal Oxygen Consumption
200-250 mL O2/min
What is the final common
pathway of all causes of death
tissue hypoxia
energy production is determined by what
metabolic rate
creation of energy is supported by what
adequate amounts of glucose and oxygen delivered to the cells
similarities between aerobic and anaerobic metabolism
- both start with glucose metabolized to pyruvate
- both produce ATP
Aerobic metabolism
-O2 present
• Pyruvate converted to acetyl-CoA, which enters the Krebs cycle
which produces carbon dioxide, water and ATP
• 1 mole glucose→ 36 moles ATP
-end product= CO2 and H2O
Anaerobic metabolism
• Pyruvate converted to lactic acid and ATP
• 1 mole glucose→ 2 moles ATP
-end product= lactic acid
monitoring what can tell you a lot about what has occurred during your pump run
lactate
why measure lactic acid in blood
-if lactic acid present, we know that there are areas in our body where anaerobic metabolism has occurred
Arterial O2 content
17-20 mL/100mL blood
Venous O2 content
12-15 mL/100mL blood
A-V O2 difference
4-6 mL/100mL blood
what is one of the best ways to increase O2 content
-increase hemaglobin
O2 delivery (& normal value)
- DO2 = Arterial content × Cardiac output
- 950-1150 mL O2/min
- Indexed: 550-650 mL O2/min/m2
O2 reserve
• The amount of oxygen left AFTER consumption
has taken place
• Venous gases returning to the heart
• A built-in physiologic buffer (in case we need it)
Normal Oxygen Reserve
- 700-800 mL O2/min
- Indexed: 450 mL O2/min/m2
How long can you use your reserve
- around 32% SvO2
- then anaerobic metabolism starts to come into play