Test 5 Flashcards
What are causes of cirrhosis of the liver? (8)
- Alcoholic liver dz
- NAFLD (fatty liver)
- Autoimmune
- Hepatitis
- Primary biliary cirrhosis
- Drug induced
- Wilson’s Dz
- Chronic R sided HF
Which type of Hepatitis is closely associated with development of cancer?
Hep C
Name 6 complications of altered liver function:
- Low albumin
- Low protein
- Low potassium
- High bilirubin
- High ammonia
- Coagulopathies
- H2O retention
What is the most common cause of encephalopathy? (hepatic or otherwise)
High ammonia levels
What are 2 medications used to lower ammonia levels/Tx encephalopathy?
Lactulose
Neomycin
Asterixis is AKA _____ and is caused from _____
Liver flap; encepalopathy (high ammonia)
Liver failure patients are hypo or hypervolemic?
Hypovolemic despite being edematous–due to third spacing
What role do the kidneys play in liver failure?
Hypovolemia causes the kidneys to be under-perfused which can cause AKI.
Kidneys excrete bilirubin.
What blood products/Tx might a liver failure pt. receive?
- PRBCs
- FFP
- Plts
- Volume rep. w/ Colloids
- Vit K
What fluid/electrolyte imbalances would you see in LF patients?
- Hypokalemia
- Decreased UOP
- IV volume depletion
- Hypoalbuminemia
Explain the TIPS procedure:
Stent placed (acts as an artificial vessel) to bypass the portal system in liver
When chronic paracentesises are no longer tolerated, what intervention can be done?
A LeVeen shunt can be placed- shunt is placed under the skin that routes the ascitic fluid from the peritoneum (more permanent drainage system)
What causes abdominal compartment syndrome?
High pressures that result in decreased perfusion to the abdominal cavity (sustained intra abdominal pressure of >20 mmHg with new organ dysfunction or failure)
Sustained IAP = MAP-IAP
Define fulminant hepatic failure and what is the major cause?
Liver failure which occurs in less than 6 months; hepatotoxic meds (acetaminophen)
Which medications are contraindicated in fulminant LF but are indicated in normal LF?
Lactulose, neomycin