test 3 part 8 Flashcards
what are some causes of reversible dementiaq
medications
alcohol
metabolic d/o
depression
CNS neoplasms
treatment options for dementia
cholinesterase inhibitors
NMDA antagonist: memantine
MAOIs
SSRIs
vitamin E and ginko biloba
if a pt with dementia is being treated with a cholinesterase inhibitor; what do you need be aware of from an anesthesia standpoint
cholinesterase inhibitors may prolong succinylcholine
what drugs are affiliated with increased development of postop delirium ?
benzodiazepines
antihistamines
anticholinergics
risk factors of postop delirium
- renal insuff/metabolic derangements
- poorly controlled pain
- polypharmacy (psychoactive drugs)
- functional impairment
- urinary retention and prescence of urinary catheter
anesthesia implications of dementia
- determine level of cognitive dysfunction
- increased risk of aspiration
- increased risk for Postop delirium
- multimodal pain management
- caution with use of benzos, antihistamines, and anticholinergics
parkinsons disease is a neurodegenerative d/o of the CNS d/t __________________________
loss of dopamine containing neurons from the pars compacta of the substantia nigra with lewy bodies
loss of dopamine in parkinsons dz causes what
- unopposed acetylcholine action: bradykinesia, rigidity, tremor, postural instability
- autonomic dysfunction : orthostatic hypotn, poor tem control, urinary retention, salivation, delayed gastric emptying
- high incidence of dysphagia
- dementia
- depression
- immobility and falls
what is the most frequently reported cause of death reported in a pt with parkinsons
pneumonia
there is no cure for parkinsons, however some meds/tx are given for symptom relief and quality of life, what are they?
- dopamine prodrug: levodopa/carbidopa
- dopamine agonists
- selective MAOIs and anticholinergics
- surgery: Deep brain stimulator
- rehab
what is the current mainstay of surgical tx in a patient with parkinsons?
deep brain stimulator
when would a dopamine agonist be the first line drug of choice in a patient with parkinsons?
if they are < 55 y/o
____________ is a dopamine precursor that is used in the intial tx of parkinsons
levodopa
__________________ inhibits the activity of the decarboxylating enzyme that is present with parkinsons
carbidopa
T/F: effectiveness of levodopa decreases as the dz progresses
true