Test 3 All in Flashcards
Hematopoesis
Blood cell production, occurs in red bone marrow of irregular bones
Hematopoetic stem cell
As the cell matures it differentiates and changes production of several different types of cells depending on the demand of the cells.
Erythropoesis
RBC Production. Stimulated by hypoxia needs protein - high protein diet needed for healing, stimulated by the kidney.
Anemia
Low oxygen in the blood
Reticulocyte
Immature RBC, measures rate at which new RBC’s enter the blood stream. Mature in 48 hours of release into blood stream. No nucleus and slightly larger than mature RBC
Hemolysis
Destruction of RBCs
Normal life span of RBCs
120 days
Leukocytes
WBCs Neutrophils, most common acute inflammatory response, monocytes have a large mononuclear cell
Lymphocytes
bcells- fever, night sweats. t cells - decide what to be.
Thrombocytes
Normal count is 150000 - 400000. Aid in blood clotting. activated when exposed to interstitial collagen from injured blood vessel, form clumps, stickiness is called adhesiveness, clumps formation is called aggultination
Coagulation cascade
Heparin acts on intrinsic factor. Coumadin acts on extrinsic factor
Spleen
Recycling center of the body. Filters out old RBCs, reuses iron from hemoglobin and returns to bone marrow. Sickle cell alters splenic function.
Red Bone Marrow and stem cells
Decrease with age, never completely deplete. medications may interfere with clotting time. chemo attacks all rapidly dividing cells (including hair)
Anemia may be related to
Decreased intake of iron, cobalamin, folic acid, and green leafy vegetables
Anemia questions for patients
Age of menarche, clotting, cramping, and amount of bleeding.
Skin in an anemia patient will look like?
skin may be pale (decreased HGB), flushing (increased HGB), jaundice (excessive hemolysis) cyanosis (low HGB, High deoxyhemoglobin) Pruritis (hodgkins), leg ulcers (sickle cell), Petechia (low platelet or clotting factor), eccymosis, hematoma.
The eyes in an anemia patient will have?
Jaundiced sclera due to accumaltion of bile pigment.
What is responsible for Coagulation of the blood?
Platelets
why does a patient who has undergone Gastric bypass surgery develop anemia?
because they cant absorb Vitamin B12 (Cobalamin)
Neutopenia
low WBC’s >4,000
The basis of cellular and humoral immune response………..
Lymphocytes (B+T cells)
Thrombocytopenia
low platelets and low thrombocytes
If you can feel a patients spleen?
STOP PALPATING SICKO
A chemo pt is at risk for?
bleeding, infection, & anemia
WBC count >11,000
WBC < 4,000
Infection
Leukopenia
Nursing Responsibility for a Bone Marrow Biopsy
Get consent, Pre-emptive medication (Conscious sedation) Versed, & Morphine, Pressure dressing after (hold for 15 min) do frequent site checks, Assess the site for bleeding (underneath them) Possible Complications: Infections and bleeding
Erythropoetin stimulates?
Bone marrow to make RBC when O2 is low. Anticipate administering Epogen SQ for management of anemia secondary to CRF
A client with case of fever, chills, and left costovertebral pain should have what kind of test started?
Clean catch urine test.
IF you have a female client who has given you a urine test, what can you expect?
If they are on their menarche you can expect RBC’s in the urine.
What is ATN?
Acute Tubular Necropsy.
If urine PH is below 4 what is this a sign of?
Respiratory or METABOLIC ACIDOSIS
If your urine sample comes back positive for streptococci, or is contaminated. What probably happened?
You touched the inside of the cup.
Yellow or brown urine sample is usually?
Pyridium. given for urinary pain. burning and urgency.
What blood chemistries should you check for in a urine sample?
BUN, Creatinine. These are expected in a client in suspected Cancer of pancreas. Run this test before chemo.
Normal urine residual should be?
<50 ml
Renal function can be checked with this? It is a better indictor than BUN.
Serum Creatinine. It is not influenced by protein and exercise.
Normal platelet life is?
9-10 days
BUN level is normally?
10-30 mg/dl
Normal Serum Creatinine levels are?
0.5 - 1.5 mg/dl
Most people in renal failure have what kind of HCO3 levels?
Low HCO3 because they are in metabolic acidosis. Normal levels are 20-30
Some chemotherapies are nephrotoxic. what needs to be monitored when patients are on chemo?
BUN, Creatanine, & Urine output
A potassium level >6 can lead to what?
MM Weakness & cardiac arrythmias. Normal levels are 3.5-5.0
Phosphorus is inversely related to?
Calcium
Nephrotic drugs alter?
Urine function. Advil and Ibuprofin are nephrotoxic.
Azotemia is?
High levels of Nitrogenous waste products in urine. Kidneys are not filtering correctly.
Who is prone for renal disorders?
Smokers, Textile workers, PAinters,
Dehydration can lead to?
UTI, Calculi, Renal failure.
Before using IVP what does the nurse need to asses for?
Seafood allergies. SHRIMP
ARF stands for?
Acute Renal Failure
The most common bacterium in UTI’s is?
E. Coli
MRI’s visualize what?
Soft tissues
Bactrim must be administered how?
On an empty stomach. 1 hour before or two hours after a meal. With a full glass of water.
Bactrim is taken for how long?
3 - 5 days. Taken on an empty stomach
If stone is present should fluids be increased to dilute?
No when stones are present, just hydrate do once stone is gone you can super hydrate to help keep new stones from forming.
While you have a UTI, you should avoid what kind of food or juice?
Citrus. It irritates the bladder.
One of the clinical manifestations of Cystitis is?
Suprapubic pain. Relieved by voiding and frequency.
The most common symptom of early bladder cancer is?
Gross painless hematuria. Either chronic or intermittent.
What is created in a radical cystectomy?
An ileal conduit
Which of the following is not a likely cause of CRF?
A. diabetes
B. HTN
C. Aplastic anermia
D. Glomerulonephritis
C. Aplastic anemia
All others cause permanent damage to the nephrons–CRF
Aplastic anemia, a life-threatening blood disorder, has no effect on the nephrons. It is characterized by pancytopenia, not renal failure
In CRF, the GFR usually is affected when how many nephrons are damaged?
A. less then 25%
B. 40-50%
C. 60-70%
D. more than 75%
D. more then 75%, damage of 25-75% = renal insufficiency
Which GI effect is not likely to occur in a client with CRF?
A. Nausea
B. anorexia
C. oral muscousal ulcerations
D. Increase Ca+ absorption
D. Increase Ca+ absorption, it is decrease r/t lack of activation of Vit D
Uremic toxins accumlate and inflame the GI mucosa–> nausea, anorexia and oral mucosal ulcerations.
CRF causes electrolye imbalnces including?
A. hypokalemia
B.hypocalcemia
C.hypomagnesemia
C.hypophosphatemia
B. Hypocalemia r/t kindey inablitity to activate vit D (needed for Ca+ absorption
All others occur r/t kidney ability to excrete them into the urine. They then accumlate in the blood
Dietary limitations to prevent complications from CRF should limit all of the following nutrients.. except??
A. sodium
B. Calcium
C. Potassium
D. Phosporous
B.Calcium, CRF patients don’t need to restrict Ca+ because hypocalcemia may occur.
Limit all others too prevent hyperkalemia, hypernatremia, and hyperphosphatemia
When assessing for CRF, you should not find?
A. lethargy and weakness
B. Ruddy skin from increased RBCs
C. HTN from Na+ and water retention
D. Adventitious breath sounds from uremic toxins
B. Ruddy skin from increased RBCs, CRF pts have anemia from decreased erythropoitin production.
They are likely to have pallor. All other s/s are typical for CRF.
Which is the appropriate question to as a 52 y/o male with post renal failure
A. Do you have and heart problems?
B. Do you have an enlarged prostate?
C. Do you have high blood pressure?
D. Have you recently had a diagnostic exam that utlized dye?
B. Do you have an enlarged prostate?
Post renal failure results from obstruction of urine from the kindey
Ask about disorders that can lead to obstruction (renal calculi, blood clots, tumors)
Heart problems = prerenal failure
HTN & dye reactions = intrarenal failure
Which hormone triggers the conversion of angiotensin I to angiotensin II
A. renin
B. aldosterone
C. antidiuretic hormone
D. adrenocorticotropic hormone
A. Renin –> HTN increases blood flow to the kindey
Aldosterone is secreted by the adrenal cortex in response to renin.
Antidiuretic hormone, screted by the hypothalmus, decrease urine production.
Adrenocortiocotropic hormone, from the anterior pititary gland, stimulates corticosteroid secretion
Which statement is INaccurate?
A. Each kindey contains millions of nephrons
B. The loop of henle is the main kindey filter
C. The kindeys receive more than 1L of blood from the heart/min
D. The afferent arterioles carry unfiltered blood from the renal artery to the glomerular capillaries
B. The loop of henle is the main kindey filter
The glomerulus is the main filtration system in the nephrons
Together with the convoluted tubules, the loop of henley concentrates(rather than filters) the urine
The kindeys (each of which contain millions of nephrons) receives1.25 liters of unfiltered blood/min
The blood is transported from the renal artery to the glomerular capillaires by the afferent arterioles.
Which findings are indictive of flid volume overload?
A. palpitations, weakness. leg cramps
B. Pericardial friction rub
C. Pleural friction rub, fever, DIB(SOB)
D. S3 <3 sounds, pulmonaary crackles and JVD
D. S3 <3 sounds, pulmonary crackles and JVD
palpitations, weakness, leg cramps = electrolyte imblance
Pericardial friction rub = pericarditis
Pleural friction rub, fever, and DIB = uremic toxins inflame the visceral and parietal pleura of the lung
The risk for developing prerenal failure is greatest in pts with?
A. <3 failure
B. Acute pyelonephritis
C. Acute glomerulonephritis
D. SLE
A. \<3 failure Disorders that decrease cardiac outout (\<3 failure), decrease he blood flow to the kindeys. If the kindeys cant compensate=prerenal failure. Renal infections ( pyelonephritits and glomerulonephritis) and SLE = intrarenal failure
In ARF - Kussmauls respirations occur due to the body trying to?
A. Decrease the blood pH
B. Exhale excess CO2
C. Increase H+ ion excretion
D. Increase the CO2 level
B. Exhale the excess CO2
This prcess beings when damged tubules prevent the syntheis of ammonia. The H+ accumulates in the blood since it can’t combine with ammonia. This decrease the blood pH. At first the body compensates by combing the H+ with bicarbs. This forms carbonic acis, which breaks down into water and CO2.
During the oliguric phase of ARF, neurological s/s result from?
A.Hypokalemia
B. hyponatremia
C. Decreased H+ ions in the blood
D.Urea and creatinine buildup in the blood
D. Urea and creatinine build up in the blood.
Unexcreated urea and creatinine build up in the blood = toxic effects on the CNS = neurological effects (lethargy/confusion)
In the diuretic phase of ARF, which of the following is true?
A.Urine output decreases
B. Glomerular filtration of blood stops
C. THe body retains K+ and Na+
D. The renal tubules cant concentrate urine
D. The renal tubules can’t concentrate urine.
During the diuretic phase, the urine output increases, the glomeruli filter the blood and the body excretes (rather then retains) K+ and Na+
Which lab test reflects the oliguric phase of ARF?
A. BUN = 34 mg/dL
B. Creatinine = 1mg/dL
C. Na+ = 158 mEq/L
D. K+ = 3.4 mEq/L
A. BUN of 34
The BUN level exceeds 20 mg/dL
The creatinine levels exceeds 1.2 mg/dL
The Na+ drops below 135
The K+ exceeds 4.5
Preneal (ARF) before the kindey, causes consists of factors outside of kindey, some of them are:
Decreased renovascular blood flow = HTN, decreased urine output, BUN 70, creatinine >2.9, specific gravity >1.040
Hypovolemia
Decreased cardica output
Decreased peripheral vascular resistance
Intrarenal (ARF) results from conditions that cause direct damage to the renal tissue, some causes are:
Infection, Drugs (mutiple nephrotoxic antibotics: genotamcyin, all mycins), infiltrating tumors, IVP contrast, prolonged prerenal ischemia, nephrotoxic injury, acute glomerulonephritis, toxemia of pregnancy, malignant HTN, systemic lupus erthematosus, interstitial nephrtits, Acute Tubular Necrosis (ATN)
Postrenal (ARF) involve mechancial obstruction of urinary outflow, some causes are:
Benign prostatic hypertrophy (BPH), bladder cancer, calculi formation (nephrolithiasis), neurmuscular disorders, prostate cancer, spinal cord disease, trauma, adhesions from surgery.
Complications of Anemia
Erythrocyte (RBC) disorders lead to hypoxia
Hypoxia accounts for and is the underlying cause of the s/s of anemia:
-DIB
-palpitations
-confusion and tachycardia in severe cases
MCV =
Mean corpusular volume (size of cell)
- microcytosis (small cells)
- macrocytosis (big cells)
MCH=
Mean corpuscular hemoglobin (color of cell)
- low is hypochromia (pale)
- high is macrocytosis (dark)
Mild symptoms of Anemia
Hgb 10-14, palpitations, dyspnea, diaphoresis
Moderate symptoms of Anemia
HgB 6-10, same symptoms as mild but at rest, dyspnea on exertion, pallor
Sever Anemia symptoms
HgB <6, irritation of oral mucosa, impaired thought processess, tachycardia, chest pain, blurred vision, pallor, depression, theres more but only the bold ones were highlighted.