Test 3

Question 1

Four polypeptide chain?

Answer 1

2 Alpha 2 Beta

Question 2

one gram of Hb can combine with?

Answer 2

1.34 mL of oxygen

Question 3

Hb saturation with O2 is a function of the PO2 and the ___________ of the oxyhemoglobin curve

Answer 3

Hb saturation with O2 is a function of the PO2 and the shape and position of the oxyhemoglobin curve.

Question 4

Factors Shifting Curve to the left

• _
• _
• _
• _, _, _, and ____
• _
• _
• _

Answer 4

• Alkalosis
• Hypothermia
• Decreased 2,3-DPG
• Hypocarbia
• Fetal Hb, methemoglobin, carboxyhemoglobin and other abnormal Hbs
• Polycythemia
• Stored blood

Question 5

Factors Shifting Curve to the right

• _
• _
• _
• _
• _
• _
• _

Answer 5

• Acidosis
• Hyperthermia
• Hypercarbia
• Increased 2.3-DPG
• Anemia
• Hypoxemia
• Abnormal Hbs

Question 6

2,3-DPG

Answer 6

• organic phosphate in RBC
• end product of glucose metabolism
• binds with hb, decreasing Hbs affinity for oxygen

Question 7

What does a left shift mean??

Answer 7

Greater affinity of Hb for oxygen. The SO2 will be higher than expected for a given PO2. (The P50 will be lower)

Question 8

What does right shift of the curve mean?

Answer 8

there is less affinty of Hb for oxygen. The SO2 will be lower than expected for a given PO2 (The P50 will be higher)

Question 9

HBS

Answer 9

Sickle Cell (Africa) - Malaria Protection

Question 10

Fetal HB

Answer 10

has 2 alpha and 2 gamma chains

**Drug induced HbF to Tx sickle cell anemia**